Mark Steven Cragg

Research interests

Antibody biology

Antibody engineering

Cancer Immunotherapy

Accepting applications from PhD students.

Research

Research groups

Member of:

Research interests

Antibody biology
Antibody engineering
Cancer Immunotherapy
Receptor Biology

Research projects

Active projects

Cragg - Bioinvent - Generation and Evaluation of Therapeutic Antibodies Targeting T Regs

Researchers:

Professor Mark Cragg

Professor Stephen Beers

Sponsor: BioInvent International AB

Cragg CRUK Understanding and Overcoming resistance to antibody therapy

Researchers:

Professor Mark Cragg

Professor Stephen Beers ,

Professor Jon Strefford ,

Doctor Yury Bogdanov ,

Doctor Stephen Thirdborough

Sponsor: Cancer Research UK

Cragg - Bioinvent - Antibody Hub

Researchers:

Professor Mark Cragg

Sponsor: BioInvent International AB

Development and characterisation of TNFR2 antibodies

Researchers:

Professor Mark Cragg

Professor Stephen Beers ,

Doctor Sean Lim ,

Doctor Yury Bogdanov

Sponsor: BioInvent International AB

Cragg - Bioinvent - Optimising antibody mediated target cell deletion (Feb 16)

Researchers:

Professor Mark Cragg

Sponsor: BioInvent International AB

The Immune Regulation of Macrophage Antibody Dependent Cellular Phagocytosis

Researchers:

Professor Mark Cragg

Doctor Stephen Thirdborough ,

Professor Stephen Beers

Sponsor: National Institutes of Health

B-cell receptor signalling in B-cell malignancies: Identifying strategies for optimal therapeutic intervention based on common and distinct responses

Researchers:

Professor Graham Packham

Professor Jon Strefford ,

Professor Francesco Forconi ,

Professor Mark Cragg

Sponsor: Cancer Research UK

Developing next generation DC-SIGN antibodies for the treatment of follicular lymphoma

Researchers:

Professor Francesco Forconi

Professor Mark Cragg ,

Doctor Sean Lim

Sponsor: Cancer Research UK

Cancer Research UK Southampton Centre - Non-Clinical Training Award

Researchers:

Professor Peter Johnson

Professor Diana Eccles ,

Professor Tim Underwood ,

Professor Stephen Beers ,

Professor Jon Strefford ,

Doctor Jeremy Blaydes ,

Professor Edd James ,

Professor John Primrose ,

Professor Gareth Thomas ,

Professor Ramsey Cutress ,

Professor Francesco Forconi ,

Professor Freda Stevenson ,

Professor Alex Mirnezami ,

Professor Mark Cragg ,

Professor Aymen Al-Shamkhani ,

Professor Anneke Lucassen ,

Professor Simon Crabb ,

Doctor Juliet Gray ,

Doctor Sean Lim ,

Doctor Ellen Copson ,

Professor Graham Packham

Sponsor: Cancer Research UK

Developing immunostimulatory antibodies to deliver agonism without toxicity

Researchers:

Professor Aymen Al-Shamkhani

Professor Jonathan Essex ,

Professor Mark Cragg ,

Professor Stephen Beers ,

Doctor Ivo Tews

Sponsor: Cancer Research UK

Completed projects

Dr S Lim (Cragg): MRC Clinical Research Training Fellowship:The Role of Fc Gamma Receptors in Regulating the Responses to Antibody Therapy

Researchers:

Professor Mark Cragg

Sponsor: Medical Research Council

Dr M Cragg 07010

Researchers:

Professor Mark Cragg

Sponsor: Blood Cancer UK

M Cragg Bioinvent Int AB Test of CD32B specific nCoDeR mAbs

Researchers:

Professor Mark Cragg

Sponsor: BioInvent International AB

Cragg- Gilead Services Inc - Combination of PI3K inhibitors and anti-CD20 mAbs

Researchers:

Professor Mark Cragg

Professor Graham Packham

Sponsor: Gilead Sciences Inc

Dr Cragg 08-0566: Role of the Pro-Survival Molecule A1 in Melanoma

Researchers:

Professor Mark Cragg

Sponsor: Worldwide Cancer Research

Cragg - Biovent

Researchers:

Professor Mark Cragg

Sponsor: BioInvent International AB

Development of Free-Flow Electrophoresis for the indentification of novel surface markers on malignant and pre-malignant B-Cells

Researchers:

Professor Mark Cragg

Sponsor: Wessex Medical Research

Dr Cragg Leukaemia Research Fund - Ref 07048: Mechanism of In-Vivo Synergy betwen Anti-CD20 Antibodies and Chemotherapy

Researchers:

Professor Mark Cragg

Sponsor: Blood Cancer UK

Therapeutic MOA and efficacy of anti-TIGIT antagonist: Comparison of isotypes and role of Fc receptor

Researchers:

Professor Mark Cragg

Doctor Sean Lim

Sponsor: iTeos Therapeutics

M Cragg 04006

Researchers:

Professor Mark Cragg

Sponsor: Blood Cancer UK

Test of CD32B specific nCoDeR mAbs

Researchers:

Professor Mark Cragg

Sponsor: BioInvent International AB

M Cragg Roche CD32B regulating modulation of anti-CD20 mAbs

Researchers:

Professor Mark Cragg

Sponsor: F. Hoffmann-La Roche Ltd

Dr M S Cragg: 08014: Role of FcgRIIb Antibodies in Immunotherapy

Researchers:

Professor Mark Cragg

Sponsor: Blood Cancer UK

Cragg Kay Kendall Trust Resistance of CLL to anti-CD20 mAbs

Researchers:

Professor Mark Cragg

Professor Graham Packham

Sponsor: The Kay Kendall Leukaemia Fund

Regulation of inhibitory receptor expression in clear cell Renal Cell Carcinoma (ccRCC)

Researchers:

Professor Mark Cragg

Sponsor: The Pathological Society of Great Britain & Ireland

M Cragg. LLR. 11054. Targetting CD85a

Researchers:

Professor Mark Cragg

Sponsor: Blood Cancer UK

Cragg - KKLF - KKL981 - Overcoming tissue-mediated resistance of CLL to anti-CD20 monoclonal antibody therapy.

Researchers:

Professor Mark Cragg

Professor Graham Packham

Sponsor: The Kay Kendall Leukaemia Fund

Dr M. Cragg: 10055 Apoptosis antibodies

Researchers:

Professor Mark Cragg

Professor Stephen Beers

Sponsor: Blood Cancer UK

M Cragg 04-427

Researchers:

Professor Mark Cragg

Sponsor: Worldwide Cancer Research

Dr Cragg: BH3-only proteins and micorenvironmental niches in the development and treatment resistance of CLL

Researchers:

Professor Mark Cragg

Sponsor: Blood Cancer UK

Cragg - CRUK - SUA Cytokine Release Assay (BI-1206)

Researchers:

Professor Mark Cragg

Sponsor: Cancer Research UK

Cragg. LLR. 12050. Optimising antibody therapy for Lymphoma.

Researchers:

Professor Mark Cragg

Professor Stephen Beers ,

Professor Jon Strefford ,

Professor Peter Johnson

Sponsor: Blood Cancer UK

iPhD Student Rotation Projects 21/22

Researchers:

Professor Mark Cragg

Sponsor: Cancer Research UK

Steele LLR 12044 autophagy in chronic lymphocytic leukaemia

Researchers:

Professor Mark Cragg ,

Professor Graham Packham

Sponsor: Blood Cancer UK

G Packham. LLR. 11053. Oxidative stress in chronic lymphocytic leukaemia

Researchers:

Professor Graham Packham

Professor Mark Cragg

Sponsor: Blood Cancer UK

Cragg, 09009, Importance of antigrenic modulation in explaining the clinical behaviour of rituximab in CLL

Researchers:

Professor Stephen Beers ,

Professor Mark Cragg

Sponsor: Blood Cancer UK

Cancer Research UK Southampton Centre - Clinical Training Award

Researchers:

Professor Peter Johnson

Professor Diana Eccles ,

Professor Stephen Beers ,

Professor Tim Underwood ,

Professor Jon Strefford ,

Doctor Jeremy Blaydes ,

Professor Edd James ,

Professor John Primrose ,

Professor Gareth Thomas ,

Professor Ramsey Cutress ,

Professor Francesco Forconi ,

Professor Freda Stevenson ,

Professor Alex Mirnezami ,

Professor Mark Cragg ,

Professor Aymen Al-Shamkhani ,

Professor Anneke Lucassen ,

Professor Simon Crabb ,

Doctor Juliet Gray ,

Doctor Sean Lim ,

Doctor Ellen Copson ,

Professor Graham Packham

Sponsor: Cancer Research UK

Beers BCRT Manipulation of macrophage FcR in breast cancer

Researchers:

Professor Stephen Beers

Professor Ramsey Cutress ,

Professor Mark Cragg

Sponsor: Breast Cancer Research Trust

Steele LLR 14040 B cell receptor signalling is modified by IL-4 in chronic lymphocytic leukaemia CLL

Researchers:

Professor Freda Stevenson ,

Professor Mark Cragg ,

Professor Graham Packham

Sponsor: Blood Cancer UK

Glennie - Bioinvent - OX40 4-1BB Development Work

Researchers:

Professor Mark Cragg

Sponsor: BioInvent International AB

Packham LLR 14045 Gordon Pillar PhD Studentship Opposing kinase activation in B-cell malignancies

Researchers:

Professor Graham Packham

Professor Francesco Forconi ,

Professor Mark Cragg

Sponsor: Blood Cancer UK

Modulating GABAergic Signalling to Augment the Immunotherapy of Solid Tumours

Researchers:

Doctor Yury Bogdanov

Professor Mark Cragg ,

Professor Stephen Beers

Sponsor: Cancer Research UK

Gray SPARKS Manipulating FC Gamma Receptors

Researchers:

Doctor Juliet Gray

Professor Stephen Beers ,

Professor Mark Cragg

Sponsor: Sparks Children's Medical Research Charity

Beers, CRUK, Validating STING Ligands as Immune Adjuvants for Antibody Therapy

Researchers:

Professor Stephen Beers

Doctor Yury Bogdanov ,

Professor Mark Cragg

Sponsor: Cancer Research UK

Cancer Research UK Southampton Centre

Researchers:

Professor Peter Johnson

Professor Diana Eccles ,

Professor Tim Underwood ,

Professor Stephen Beers ,

Professor Jon Strefford ,

Doctor Jeremy Blaydes ,

Professor Edd James ,

Professor John Primrose ,

Professor Gareth Thomas ,

Professor Ramsey Cutress ,

Professor Francesco Forconi ,

Professor Freda Stevenson ,

Professor Alex Mirnezami ,

Professor Mark Cragg ,

Professor Aymen Al-Shamkhani ,

Professor Anneke Lucassen ,

Professor Simon Crabb ,

Doctor Juliet Gray ,

Doctor Sean Lim ,

Doctor Ellen Copson ,

Professor Graham Packham

Sponsor: Cancer Research UK

The role of FcRIIb in a-Syn toxicity and propagation in Parkinsons disease

Researchers:

Professor Jessica Teeling

Doctor Ali Roghanian ,

Professor Mark Cragg

Sponsor: The Micheal J. Fox Foundation for Parkinson's Research

Strefford LLR 12036 Importance of SF3B1 mutations

Researchers:

Professor Jon Strefford

Professor Mark Cragg ,

Doctor Igor Vorechovsky

Sponsor: Blood Cancer UK

Aquinox Screening Project NXT-POC-01 MTA2

Researchers:

Professor Graham Packham

Professor Francesco Forconi ,

Professor Mark Cragg

Sponsor: Aquinox Pharmaceuticals (Canada) Inc

Dr S. Beers: C34592/A12343 FCR Polarisation in Macrophages

Researchers:

Professor Stephen Beers

Professor Mark Cragg

Sponsor: Cancer Research UK

Glennie - CRUK C1477/A20537 - Developing Immunomodulatory Monoclonal Antibodies to Promote Cancer Immunity

Researchers:

Professor Mark Cragg

Sponsor: Cancer Research UK

S Beers - 15027 - Understanding the regulation of antibody therapy by NOTCH1 mutations in CLL

Researchers:

Professor Stephen Beers

Professor Jon Strefford ,

Professor Mark Cragg

Sponsor: Blood Cancer UK

Lim - CRUK - C30010/A15269 - Understanding & boosting T-cell transfer therapy in cancer with immunostimulatory antibodies

Researchers:

Doctor Sean Lim

Professor Mark Cragg

Sponsor: Cancer Research UK

Steele - Janssen - Overcoming resistance mechanisms to ibrutinab conferred by the lymph node microenvironment

Researchers:

Professor Mark Cragg

Sponsor: Janssen Research & Development LLC

Susceptibility of Patient derived xenograph (PDX) models of Leukemia/lymphoma to cerdulatinib alone or in combination with venetoclax or rituximab

Researchers:

Professor Mark Cragg ,

Professor Graham Packham

Sponsor: Portola Pharmaceuticals

Steele - KKLF - Investigating the impact of interleukin-4 in CLL Biology

Researchers:

Professor Jon Strefford ,

Professor Francesco Forconi ,

Professor Mark Cragg ,

Professor Graham Packham

Sponsor: The Kay Kendall Leukaemia Fund

External roles and responsibilities

Name: Scientific Commission for LabEx MAbImprove (Event)

Role: Member

Year: 2015 -

Name: Latvian Biomedical Research & Study Centre Scientific Advisory Board (Event)

Role: Member

Year: 2015 - 2020

Name: Member of Blood Cancer UK Expert Reference Group (Event)

Role: Member

Year: 2020 -

Name: Scientific Research Committee Prostate Cancer UK (Event)

Role: Member

Year: 2017 - 2022

Name: Scientific Advisory Board BioInvent international (External organisation)

Role: Member

Year: 2011 -

Name: Scientific Advisory Board BioInvent international (External organisation)

Role: Chair

Year: 2019 -

Name: Director MRC DTP Translational Biosciences (Event)

Role: Chair

Year: 2020 -

Name: Member of New Agents Committee (Cancer Research UK) (Event)

Role: Member

Year: 2022 -

Professor Mark Cragg

Research interests

Connect with Mark

Research

Research groups

Research interests

Research projects

Active projects

Completed projects

Publications

Supervision

Current PhD Students

External roles and responsibilities

Biography

Prizes