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Research project

The role of Factor inhibiting HIF (FIH) in the development of idiopathic pulmonary fibrosis (IPF)

  • Research groups:
  • Lead researcher:
    Dr Yihua Wang
  • Research funder:
    The Academy of Medical Sciences
  • Status:
    Not active

Staff

Lead researcher

Dr Yihua Wang

Associate Professor

Research interests

  • Cell Signalling in Disease
  • Epithelial-Mesenchymal Crosstalk
  • Pulmonary Fibrosis

Collaborating research institutes, centres and groups

Cell and Developmental Biology

We explore how molecular interactions between proteins and small molecules, defined at atomic resolution, govern biochemical output and in turn control cell behaviour.

Research outputs

Paracrine SPARC signaling dysregulates alveolar epithelial barrier integrity and function in lung fibrosis
Franco Conforti,
Robert Ridley,
Christopher J Brereton,
Aiman Alzetani,
Mark Jones,
Donna Davies,
Paul Skipp,
Yihua Wang,
Christian Ottensmeier,
B. Marshall,
Sophie Fletcher,
Luca Richeldi,
Benjamin Johnson,
&
, 2020 , Cell Death and Discovery , 6
DOI: 10.1038/s41420-020-0289-9
Type: article
ASPP1 deficiency promotes epithelial-mesenchymal transition, invasion and metastasis in colorectal cancer
Dian Liu,
Ayse Ertay,
Charlotte Hill,
Yilu Zhou,
Juanjuan Li,
Yanmei Zou,
Hong Qiu,
Xianglin Yuan,
Robert Ewing,
Xin Lu,
Hua Xiong,
& Yihua Wang
, 2020 , Cell Death and Disease , 11 (4)
DOI: 10.1038/s41419-020-2415-2
Type: article
WDHD1 is essential for the survival of PTEN-inactive triple negative breast cancer
Ayse Ertay,
Huiquan Liu,
Dian Liu,
Ping Peng,
Charlotte Hill,
Hua Xiong,
David Hancock,
Xianglin Yuan,
Marcin Przewloka,
Mark Coldwell,
Michael Howell,
Paul Skipp,
Robert Ewing,
Julian Downward,
& Yihua Wang
, 2020 , Cell Death and Disease
DOI: 10.1038/s41419-020-03210-5
Type: article
Viral infection increases the risk of idiopathic pulmonary fibrosis: A meta-analysis
Gaohong Sheng,
Peng Chen,
Yanqiu Wei,
Huihui Yue,
Jiaojiao Chu,
Jianping Zhao,
Yihua Wang,
Wanguang Zhang,
& Hui-Lan Zhang
, 2020 , Chest , 157 (5) , 1175--1187
DOI: 10.1016/j.chest.2019.10.032
Type: article
Deconvolution of RNA-seq analysis of hyperbaric oxygen-treated mice lungs reveals mesenchymal cell subtype changes
Yuan Yuan,
Yilu Zhou,
Yali Li,
Charlotte Hill,
Robert Ewing,
Mark Jones,
Donna Davies,
Zhenglin Jiang,
& Yihua Wang
, 2020 , International Journal of Molecular Sciences , 21 (4) , 1--19
DOI: 10.3390/ijms21041371
Type: article