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Research project

The role of Factor inhibiting HIF (FIH) in the development of idiopathic pulmonary fibrosis (IPF)

  • Research groups:
  • Lead researcher:
    Dr Yihua Wang
  • Research funder:
    The Academy of Medical Sciences
  • Status:
    Not active

Staff

Lead researcher

Dr Yihua Wang

Associate Professor

Research interests

  • Cell Signalling in Disease
  • Epithelial-Mesenchymal Crosstalk
  • Pulmonary Fibrosis

Collaborating research institutes, centres and groups

Cell and Developmental Biology

We explore how molecular interactions between proteins and small molecules, defined at atomic resolution, govern biochemical output and in turn control cell behaviour.

Research outputs

Autophagy inhibition-mediated epithelial–mesenchymal transition augments local myofibroblast differentiation in pulmonary fibrosis
Charlotte Hill,
Juanjuan Li,
Dian Liu,
Franco Conforti,
Christopher J. Brereton,
Liudi Yao,
Yilu Zhou,
Aiman Alzetani,
Serena J. Chee,
Ben G. Marshall,
Sophie V. Fletcher,
David Hancock,
Christian H. Ottensmeier,
Andrew J. Steele,
Julian Downward,
Luca Richeldi,
Xin Lu,
Donna E. Davies,
Mark G. Jones,
Yihua Wang,
&
, 2019 , Cell Death and Disease , 10 (8)
DOI: 10.1038/s41419-019-1820-x
Type: article
Autophagy inhibition specifically promotes epithelial-mesenchymal transition and invasion in RAS-mutated cancer cells
Yihua Wang,
Hua Xiong,
Dian Liu,
Charlotte Hill,
Ayse Ertay,
Juanjuan Li,
Yanmei Zou,
Paul Miller,
Eileen White,
Julian Downward,
Robert Goldin,
Xianglin Yuan,
& Xin Lu
, 2019 , Autophagy , 15 (5) , 886--899
DOI: 10.1080/15548627.2019.1569912
Type: article
SGLT1 is required for the survival of triple negative breast cancer cells via potentiation of EGFR activity
Huiquan Liu,
Ayse Ertay,
Ping Peng,
Juanjuan Li,
Dian Liu,
Hua Xiong,
Yanmei Zou,
Hong Qiu,
David Hancock,
Xianglin Yuan,
Wei-Chien Huang,
Robert Ewing,
Julian Downward,
& Yihua Wang
, 2019 , Molecular Oncology
DOI: 10.1002/1878-0261.12530
Type: article
Paracrine signalling during ZEB1-mediated epithelial-mesenchymal transition augments local myofibroblast differentiation in lung fibrosis.
Liudi Yao,
Franco Conforti,
Charlotte Hill,
,
Joseph Bell,
Leena Drawater,
Juanjuan Li,
Dian Liu,
Hua Xiong,
Aiman Alzetani,
Serena J. Chee,
Ben G. Marshall,
Sophie V. Fletcher,
David Hancock,
Mark Coldwell,
Xianglin Yuan,
Christian H. Ottensmeier,
Julian Downward,
Jane E. Collins,
Rob M. Ewing,
Luca Richeldi,
Paul Skipp,
Mark G. Jones,
Donna E. Davies,
& Yihua Wang
, 2018 , Cell Death and Differentiation , 26 (5) , 943--957
DOI: 10.1038/s41418-018-0175-7
Type: article
ELF3 is an antagonist of oncogenic-signalling-induced expression of EMT-TF ZEB1
D. Liu,
Y. Skomorovska,
J. Song,
E. Bowler,
R. Harris,
M. Ravasz,
S. Bai,
M. Ayati,
K. Tamai,
M. Koyuturk,
X. Yuan,
Z. Wang,
Y. Wang,
& R.M. Ewing
, 2018 , Cancer Biology & Therapy , 1--11
DOI: 10.1080/15384047.2018.1507256
Type: article