Brodzki EPSRC Joining the Dots

Staff

Lead researchers

Professor Jacek Brodzki

Head of School

Research interests

Topological data analysis
Applications of topology to medicine, biology, chemistry, physics, computer science
Noncommutative Geometry

Connect with Jacek

Email: J.Brodzki@soton.ac.uk

Other researchers

Professor Jeremy Frey

Professor of Physical Chemistry

Connect with Jeremy

Email: J.G.Frey@soton.ac.uk

Professor Ratko Djukanovic

Professor of Medicine

Research interests

Professor Djukanovic has a lifelong interest in asthma, especially its severe forms. where his focus is on: 1) underlying pathobiological mechanisms of asthma, 2) stratification of asthma into clinical phenotypes and mechanism-based endotypes, 3) unmet needs of severe asthma management. He also has an interest in the mechanisms and treatments of severe viral infections of the lung.
Underlying mechanisms of asthma: Professor Djukanovic has conducted pioneer studies into the pathology of asthma, applying research bronchoscopy (with endobronchial biopsy and bronchoalveolar lavage) and sputum induction. He led the initial task forces which defined the use of these two techniques, thereby paving the way for standardised research approches that enabled in-depth descriptions of the roles of various inflammatory cells and their mediators. He developed an explant model, consisting of bronchial biopsies placed into tissue culture, that could be stimulated ex vivo with relevant triggers, applying as needed, novel agents not yet approved for in vivo use in humans volunteers.
Stratification of asthma into clinical phenotypes and mechanism-based endotypes: Professor Djukanovic led the discovery of biomarkers using omics technology (transcriptomics, proteomics, lipidomics, breathomics). After the first ever study of transcriptomics biomarkers in the epithelium of patients with Chronic Obstructive Pulmonary Disease (COPD), together with a colleague from Amsterdam and two colleagues from Imperial College, London, he created a large (€27 milllion) programme for severe asthma (U-BIOPRED), funded by the EU Innovative Medicines Initiative. This has resulted in more than 100 publications, providing insight into novel phenotypes and endotypes of asthma.

Connect with Ratko

Email: rd1@soton.ac.uk

Professor Mahesan Niranjan

ISIS Chair

Connect with Mahesan

Email: mn@ecs.soton.ac.uk

Professor Peter Smith BSc, PhD, MA, FRSB

Professor of Life Sciences

Connect with Peter

Email: P.J.Smith@soton.ac.uk

Collaborating research institutes, centres and groups

Research outputs

Improved understanding of aqueous solubility modeling through topological data analysis

Mariam Pirashvili, Jacek Brodzki, Francisco Belchi guillamon, Mahesan Niranjan, Jeremy G. Frey & Lee Steinberg, 2018, Journal of Cheminformatics, 10

DOI: 10.1186/s13321-018-0308-5

Type: article

Symmetric cohomology of groups

2018, Journal of Algebra, 509, 397-418

DOI: 10.1016/j.jalgebra.2018.05.020

Type: article

Large-scale label-free quantitative mapping of the sputum proteome

James Schofield, Dominic Burg, Joost Brandsma, Doroteya kancheva K Staykova, Aruna Bansal, B.L. Nicholas, Caterina Folisi, Aruna Bansal, Ben Nicholas, Yang Xian, Anthony Rowe, Julie Corfield, Susan Wilson, Jonathan Ward, Rene Lutter, Louise Fleming, Dominick E. Shaw, Per S. Bakke, Massimo Caruso, Sven-Erik Dahlén, Stephen J. Fowler, Simone Hashimoto, Ildiko Horvath, Peter Howarth, Norbert Krug, Paolo Montuschi, Marek Sanak, Thomas Sandstrom, Florian Singer, Charles Auffray, Kai Sun, Ioannis Pandis, Ana R. Sousa, Ian M. Adcock, Kian Fan Chung, Peter J. Sterk, Ratko Djukanovic & Paul Skipp, 2018, Journal of Proteome Research, 17(6), 1997-2248

DOI: 10.1021/acs.jproteome.8b00018

Type: article

Exactness of locally compact groups

Jacek Brodzki, Christopher Cave & Kang Li, 2017, Advances in Mathematics, 312, 209-233

DOI: 10.1016/j.aim.2017.03.020

Type: article

The periodic cyclic homology of crossed products of finite type algebras

Jacek Brodzki, Shantanu Dave & Victor Nistor, 2017, Advances in Mathematics, 306, 494-523

DOI: 10.1016/j.aim.2016.10.025

Type: article

Robust portfolio risk minimization using the graphical lasso

Tristan Millington & Mahesan Niranjan, 2017