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Research project

Defining the role of ZEB1-dependent epithelial-mesenchymal crosstalk in lung fibrosis

  • Research groups:
  • Lead researcher:
    Dr Yihua Wang
  • Research funder:
    Medical Research Council
  • Status:
    Not active

Project overview

Idiopathic pulmonary fibrosis (IPF) is a life-threatening condition of the lungs where tissue becomes thickened, stiff, and scarred, limiting the amount of oxygen getting into the blood. The aim of this project is to provide effective targeted therapies for sufferers to reduce symptoms of this devastating disease and improve their quality of life as well as to identify biomarkers for IPF patients.

Staff

Lead researcher

Dr Yihua Wang

Associate Professor

Research interests

  • Cell Signalling in Disease
  • Epithelial-Mesenchymal Crosstalk
  • Pulmonary Fibrosis

Collaborating research institutes, centres and groups

Cell and Developmental Biology

We explore how molecular interactions between proteins and small molecules, defined at atomic resolution, govern biochemical output and in turn control cell behaviour.

Research outputs

Autophagy in pulmonary fibrosis: friend or foe?
Charlotte Hill,
& Yihua Wang
, 2022 , Genes and Diseases , 9 (6) , 1594--1607
DOI: 10.1016/j.gendis.2021.09.008
Type: review
Proteomic characterization of GSK3β knockout shows altered cell adhesion and metabolic pathway utilisation in colorectal cancer cells
Emily Bowler-Barnett,
Francisco D. Martinez-Garcia,
Matthew Sherwood,
Ahood Aleidan,
Steve John,
Sara Weston,
Yihua Wang,
Nullin Divecha,
Paul Skipp,
& Rob M. Ewing
, 2021 , PLoS ONE , 16 (11) , e0246707
DOI: 10.1371/journal.pone.0246707
Type: article
3-month, 6-month, 9-month, and 12-month respiratory outcomes in patients following COVID-19-related hospitalisation: a prospective study
Xiaojun Wu,
Xiaofan Liu,
Yilu Zhou,
Hongying Yu,
Ruiyun Li,
Qingyuan Zhan,
Fang Ni,
Si Fang,
Yang Lu,
Xuhong Ding,
Hailing Liu,
Robert Ewing,
Mark Jones,
Yi Hu,
Hanxiang Nie,
& Yihua Wang
, 2021 , The Lancet Respiratory Medicine
DOI: 10.1016/S2213-2600(21)00174-0
Type: article
Quantitative Proteomic Analysis in Alveolar Type II Cells Reveals the Different Capacities of RAS and TGF-β to Induce Epithelial–Mesenchymal Transition
Yilu Zhou,
Charlotte Hill,
Liudi Yao,
Juanjuan Li,
David Hancock,
Julian Downward,
Mark Jones,
Donna Davies,
Robert Ewing,
Paul Skipp,
& Yihua Wang
, 2021 , Frontiers in Molecular Biosciences , 8
DOI: 10.3389/fmolb.2021.595712
Type: article
Respiratory outcomes in patients following COVID-19-related hospitalisation: a meta-analysis
Tao Guo,
Fangfang Jiang,
Yufei Liu,
Yunpeng Zhao,
Yiran Li,
& Yihua Wang
, 2021 , Frontiers in Molecular Biosciences , 8
DOI: 10.3389/fmolb.2021.750558
Type: article