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Research project

Defining the role of ZEB1-dependent epithelial-mesenchymal crosstalk in lung fibrosis

  • Research groups:
  • Lead researchers:
    Dr Yihua Wang
  • Research funder:
    Medical Research Council
  • Status:
    Not active

Project overview

Idiopathic pulmonary fibrosis (IPF) is a life-threatening condition of the lungs where tissue becomes thickened, stiff, and scarred, limiting the amount of oxygen getting into the blood. The aim of this project is to provide effective targeted therapies for sufferers to reduce symptoms of this devastating disease and improve their quality of life as well as to identify biomarkers for IPF patients.

Staff

Lead researchers

Dr Yihua Wang

Associate Professor
Research interests
  • Cell Signalling in Disease
  • Epithelial-Mesenchymal Crosstalk
  • Pulmonary Fibrosis
Connect with Yihua

Email: yihua.wang@soton.ac.uk

Collaborating research institutes, centres and groups

Research outputs

Respiratory outcomes in patients following COVID-19-related hospitalisation: a meta-analysis
Tao Guo, Fangfang Jiang, Yufei Liu, Yunpeng Zhao, Yiran Li & Yihua Wang, 2021, Frontiers in Molecular Biosciences, 8
DOI: 10.3389/fmolb.2021.750558
Type: article
Bidirectional epithelial-mesenchymal crosstalk provides self-sustaining profibrotic signals in pulmonary fibrosis
Liudi Yao, Yilu Zhou, Juanjuan Li, Leanne Wickens, Franco Conforti, Anna Simron Rattu, Fathima M Ibrahim, Aiman Alzetani, Benjamin Marshall, Sophie Fletcher, David Hancock, Timothy Wallis, Julian Downward, Robert Ewing, Luca Richeldi, Paul Skipp, Donna Davies, Mark Glynne Jones & Yihua Wang, 2021, Journal of Biological Chemistry, 297(3)
DOI: 10.1016/j.jbc.2021.101096
Type: article
3-month, 6-month, 9-month, and 12-month respiratory outcomes in patients following COVID-19-related hospitalisation: a prospective study
Xiaojun Wu, Xiaofan Liu, Yilu Zhou, Hongying Yu, Ruiyun Li, Qingyuan Zhan, Fang Ni, Si Fang, Yang Lu, Xuhong Ding, Hailing Liu, Robert Ewing, Mark Jones, Yi Hu, Hanxiang Nie & Yihua Wang, 2021, The Lancet Respiratory Medicine
DOI: 10.1016/S2213-2600(21)00174-0
Type: article
Quantitative Proteomic Analysis in Alveolar Type II Cells Reveals the Different Capacities of RAS and TGF-β to Induce Epithelial–Mesenchymal Transition
Yilu Zhou, Charlotte Hill, Liudi Yao, Juanjuan Li, David Hancock, Julian Downward, Mark Jones, Donna Davies, Robert Ewing, Paul Skipp & Yihua Wang, 2021, Frontiers in Molecular Biosciences, 8
DOI: 10.3389/fmolb.2021.595712
Type: article
Temporal radiographic changes in COVID-19 patients: relationship to disease severity and viral clearance
Xiaofan Liu, Hong Zhou, Yilu Zhou, Xiaojun Wu, Yang Zhao, Yang Lu, Weijun Tan, Mingli Yuan, Xuhong Ding, Jinjing Zou, Ruiyun Li, Hailing Li, Robert Ewing, Yi Hu, Hanxiang Nie & Yihua Wang, 2020, Scientific Reports, 10(1)
DOI: 10.1038/s41598-020-66895-w
Type: article
WDHD1 is essential for the survival of PTEN-inactive triple negative breast cancer
Ayse Ertay, Huiquan Liu, Dian Liu, Ping Peng, Charlotte Hill, Hua Xiong, David Hancock, Xianglin Yuan, Marcin Przewloka, Mark Coldwell, Michael Howell, Paul Skipp, Robert Ewing, Julian Downward & Yihua Wang, 2020, Cell Death and Disease
DOI: 10.1038/s41419-020-03210-5
Type: article
Different laboratory abnormalities in COVID-19 patients with hypertension or diabetes
Xiaojun Wu, Tong Wang, Yilu Zhou, Xiaofan Liu, Hong Zhou, Yang Lu, Weijun Tan, Mingli Yuan, Xuhong Ding, Jinjing Zou, Ruiyun Li, Hailing Liu, Robert Ewing, Yi Hu, Hanxiang Nie & Yihua Wang, 2020, Virologica Sinica, 1-4
DOI: 10.1007/s12250-020-00296-1
Type: letterEditorial