Dr Marcin Przewloka is a Lecturer in Molecular Cell Biology within Biological Sciences at the University of Southampton. His research interests include control of mitotic cell division, chromosome biology, the role of centromere and kinetochore in proper chromosome segregation, involvement of post-translational modifications of proteins in the regulation of the cell cycle, and the fomation and biological role of multi-protein complexes in cell biology.
Faithful transmission of the genetic material to daughter cells is key to maintain genomic integrity at a cellular and organismal level. For this to happen proper chromosome condensation and segregation must occur in a controlled and coordinated manner. Chromosome segregation errors may potentially lead to inheritable abnormalities with severe consequences. Also, aneuploidy and chromosome instability, which arise from chromosomal aberrations, are hallmarks of cancer cells. It is therefore very important to understand mechanisms governing formation of chromosomes and their accurate segregation during cell division.
Properly functioning kinetochores, very large multiprotein complexes formed on mitotic centromeres, are a prerequisite for correct chromosome segregation. They constitute a dynamic but in the same time very robust connection between chromosomes and microtubules of the mitotic spindle. I study kinetochores’ composition and the regulation of their assembly in early mitosis. I am interested in how protein interaction networks respond to a constantly changing environment at the chromosome-microtubule interface. Also, my studies address a general question of how kinetochore signalling is embedded in and connected to other pathways regulating cell division and more broadly, cell physiology. To gain insight into these fundamental processes I employ integrated multi-disciplinary approach, which uses biochemistry, structural biology, cell biology and proteomics methodologies. I hope that this multi-angle, systemic and collaborative strategy is going to give a deeper and more complete understanding of the kinetochore function in health and disease.
BIOL1030 How to Think Like a Scientist
BIOL1025 Fundamentals of Cell Biology and Physiology
BIOL1032 Introduction to Cell Biology and Physiology
BIOL3034 Laboratory Research Project
BIOL3064 Cancer Chromosome Biology
BIOL6071 Cancer Chromosome Biology
BIOL3001 Current Topics in Cell and Developmental Biology
BIOL6021 Current Topics in Cell and Developmental Biology
BIOL6011 Advanced Library Project
BIOL6013 Advanced Research Project (MSci)
2016-present: Lecturer in Molecular Cell Biology. University of Southampton, UK
2005-2016: Research Associate. Department of Genetics, University of Cambridge, Cambridge, UK
2003-2005: Research Associate. Department of Cell Biology, Albert Einstein College of Medicine, New York, USA
2000-2003: Postdoctoral Research Associate. Bioscience Division, Los Alamos National Laboratory, New Mexico, USA
2018: PGCAP - Postgraduate Certificate in Academic Practice, University of Southampton, UK
2000: PhD. Department of Biology, University of Warsaw, Poland
1995: MSc. Department of Biology, University of Warsaw, Poland