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Research project

Defining the role of ZEB1-dependent epithelial-mesenchymal crosstalk in lung fibrosis

  • Research groups:
  • Lead researcher:
    Dr Yihua Wang
  • Research funder:
    Medical Research Council
  • Status:
    Not active

Project overview

Idiopathic pulmonary fibrosis (IPF) is a life-threatening condition of the lungs where tissue becomes thickened, stiff, and scarred, limiting the amount of oxygen getting into the blood. The aim of this project is to provide effective targeted therapies for sufferers to reduce symptoms of this devastating disease and improve their quality of life as well as to identify biomarkers for IPF patients.

Staff

Lead researcher

Dr Yihua Wang

Associate Professor

Research interests

  • Cell Signalling in Disease
  • Epithelial-Mesenchymal Crosstalk
  • Pulmonary Fibrosis

Collaborating research institutes, centres and groups

Cell and Developmental Biology

We explore how molecular interactions between proteins and small molecules, defined at atomic resolution, govern biochemical output and in turn control cell behaviour.

Research outputs

Bidirectional epithelial-mesenchymal crosstalk provides self-sustaining profibrotic signals in pulmonary fibrosis
Liudi Yao,
Yilu Zhou,
Juanjuan Li,
Leanne Wickens,
Franco Conforti,
Anna Simron Rattu,
Fathima M Ibrahim,
Aiman Alzetani,
Benjamin Marshall,
Sophie Fletcher,
David Hancock,
Timothy Wallis,
Julian Downward,
Robert Ewing,
Luca Richeldi,
Paul Skipp,
Donna Davies,
Mark Glynne Jones,
& Yihua Wang
, 2021 , The Journal of Biological Chemistry , 297 (3)
DOI: 10.1016/j.jbc.2021.101096
Type: article
Paracrine SPARC signaling dysregulates alveolar epithelial barrier integrity and function in lung fibrosis
Franco Conforti,
Robert Ridley,
Christopher J Brereton,
Aiman Alzetani,
Mark Jones,
Donna Davies,
Paul Skipp,
Yihua Wang,
Christian Ottensmeier,
B. Marshall,
Sophie Fletcher,
Luca Richeldi,
Benjamin Johnson,
&
, 2020 , Cell Death and Discovery , 6
DOI: 10.1038/s41420-020-0289-9
Type: article
ASPP1 deficiency promotes epithelial-mesenchymal transition, invasion and metastasis in colorectal cancer
Dian Liu,
Ayse Ertay,
Charlotte Hill,
Yilu Zhou,
Juanjuan Li,
Yanmei Zou,
Hong Qiu,
Xianglin Yuan,
Robert Ewing,
Xin Lu,
Hua Xiong,
& Yihua Wang
, 2020 , Cell Death and Disease , 11 (4)
DOI: 10.1038/s41419-020-2415-2
Type: article
Temporal radiographic changes in COVID-19 patients: relationship to disease severity and viral clearance
Xiaofan Liu,
Hong Zhou,
Yilu Zhou,
Xiaojun Wu,
Yang Zhao,
Yang Lu,
Weijun Tan,
Mingli Yuan,
Xuhong Ding,
Jinjing Zou,
Ruiyun Li,
Hailing Li,
Robert Ewing,
Yi Hu,
Hanxiang Nie,
& Yihua Wang
, 2020 , Scientific Reports , 10 (1)
DOI: 10.1038/s41598-020-66895-w
Type: article
Different laboratory abnormalities in COVID-19 patients with hypertension or diabetes
Xiaojun Wu,
Tong Wang,
Yilu Zhou,
Xiaofan Liu,
Hong Zhou,
Yang Lu,
Weijun Tan,
Mingli Yuan,
Xuhong Ding,
Jinjing Zou,
Ruiyun Li,
Hailing Liu,
Robert Ewing,
Yi Hu,
Hanxiang Nie,
& Yihua Wang
, 2020 , Virologica Sinica , 1--4
DOI: 10.1007/s12250-020-00296-1
Type: letterEditorial