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Research project

The role of Factor inhibiting HIF (FIH) in the development of idiopathic pulmonary fibrosis (IPF)

  • Research groups:
  • Lead researchers:
    Dr Yihua Wang
  • Research funder:
    The Academy of Medical Sciences
  • Status:
    Not active

Staff

Lead researchers

Dr Yihua Wang

Associate Professor
Research interests
  • Cell Signalling in Disease
  • Epithelial-Mesenchymal Crosstalk
  • Pulmonary Fibrosis
Connect with Yihua

Email: yihua.wang@soton.ac.uk

Collaborating research institutes, centres and groups

Research outputs

Autophagy in pulmonary fibrosis: friend or foe?
Charlotte Hill & Yihua Wang, 2022, Genes and Diseases, 9(6), 1594-1607
DOI: 10.1016/j.gendis.2021.09.008
Type: review
Integrated analysis reveals effects of bioactive ingredients from Limonium Sinense (Girard) Kuntze on hypoxia-inducible factor (HIF) activation
Hualong Zhao, Siyuan Wang, Yilu Zhou, Ayse Ertay, Philip Williamson, Robert Ewing, Xinhui Tang, Jialian Wang & Yihua Wang, 2022, Frontiers in Plant Science, 13
DOI: 10.3389/fpls.2022.994036
Type: article
Pseudohypoxic HIF pathway activation dysregulates collagen structure-function in human lung fibrosis
Christopher J. Brereton, Liudi Yao, Elizabeth R. Davies, Yilu Zhou, Milica Vukmirovic, Joseph A. Bell, Siyuan Wang, Robert A. Ridley, Lareb S.N. Dean, Orestis G. Andriotis, Franco Conforti, Lennart Brewitz, Soran Mohammed, Timothy Wallis, Ali Tavassoli, Rob M. Ewing, Aiman Alzetani, Benjamin G. Marshall, Sophie V. Fletcher, Philipp J. Thurner, Aurelie Fabre, Naftali Kaminski, Luca Richeldi, Atul Bhaskar, Christopher J. Schofield, Matthew Loxham, Donna E. Davies, Yihua Wang & Mark G. Jones, 2022, eLife, 11
DOI: 10.7554/eLife.69348
Type: article
Bidirectional epithelial-mesenchymal crosstalk provides self-sustaining profibrotic signals in pulmonary fibrosis
Liudi Yao, Yilu Zhou, Juanjuan Li, Leanne Wickens, Franco Conforti, Anna Simron Rattu, Fathima M Ibrahim, Aiman Alzetani, Benjamin Marshall, Sophie Fletcher, David Hancock, Timothy Wallis, Julian Downward, Robert Ewing, Luca Richeldi, Paul Skipp, Donna Davies, Mark Glynne Jones & Yihua Wang, 2021, Journal of Biological Chemistry, 297(3)
DOI: 10.1016/j.jbc.2021.101096
Type: article
Quantitative Proteomic Analysis in Alveolar Type II Cells Reveals the Different Capacities of RAS and TGF-β to Induce Epithelial–Mesenchymal Transition
Yilu Zhou, Charlotte Hill, Liudi Yao, Juanjuan Li, David Hancock, Julian Downward, Mark Jones, Donna Davies, Robert Ewing, Paul Skipp & Yihua Wang, 2021, Frontiers in Molecular Biosciences, 8
DOI: 10.3389/fmolb.2021.595712
Type: article
WDHD1 is essential for the survival of PTEN-inactive triple negative breast cancer
Ayse Ertay, Huiquan Liu, Dian Liu, Ping Peng, Charlotte Hill, Hua Xiong, David Hancock, Xianglin Yuan, Marcin Przewloka, Mark Coldwell, Michael Howell, Paul Skipp, Robert Ewing, Julian Downward & Yihua Wang, 2020, Cell Death and Disease
DOI: 10.1038/s41419-020-03210-5
Type: article
Paracrine SPARC signaling dysregulates alveolar epithelial barrier integrity and function in lung fibrosis
Franco Conforti, Robert Ridley, Christopher J Brereton, Aiman Alzetani, Mark Jones, Donna Davies, Paul Skipp, Yihua Wang, Christian Ottensmeier, B. Marshall, Sophie Fletcher, Luca Richeldi & Benjamin Johnson, 2020, Cell Death and Discovery, 6
DOI: 10.1038/s41420-020-0289-9
Type: article