Integrative Molecular Phenotyping Centre

Publications

Browse our publications catalogue to learn about our research.

Blood gene expression predicts intensive care unit admission in hospitalised patients with COVID-19

Rebekah Penrice-Randal,

Xiaofeng Dong,

Andrew George Shapanis,

Aaron Gardner,

Nicholas Harding,

Jelmer Legebeke,

Jenny Lord,

Andres F Vallejo,

Stephen Poole,

Nathan J Brendish,

Catherine Hartley,

Anthony P Williams,

Gabrielle Wheway,

Marta E Polak,

Fabio Strazzeri,

James P R Schofield,

Paul J Skipp,

Julian A Hiscox,

Tristan W Clark,

& Diana Baralle

, 2022 , Frontiers in Immunology , 13

DOI: 10.3389/fimmu.2022.988685

Type: article

Identification of neoantigens in oesophageal adenocarcinoma

Ben Nicholas,

Alistair Bailey,

Katy J. McCann,

Oliver Wood,

Robert C Walker,

Robert Parker,

Nicola Ternette,

Tim Elliott,

Tim J Underwood,

Peter Johnson,

& Paul Skipp

, 2022 , Immunology , 168 (3) , 420 -- 431

DOI: 10.1111/imm.13578

Type: article

Operation Moonshot: rapid translation of a SARS-CoV-2 targeted peptide immunoaffinity liquid chromatography-tandem mass spectrometry test from research into routine clinical use.

Jenny Hällqvist ,

Dan Lane,

Andrew Shapanis,

Paul Skipp,

Benjamin Nicholas,

& Alistair Bailey

, 2022 , Clinical Chemistry and Laboratory Medicine , 61 (2) , 302--310

DOI: 10.1515/cclm-2022-1000

Type: article

Clinical and transcriptomic features of persistent exacerbation-prone severe asthma in U-BIOPRED cohort

Uruj Hoda,

Stelios Pavlidis,

Aruna T Bansal,

Kentaro Takahashi,

Sile Hu,

Francois Ng Kee Kwong,

Christos Rossios,

Kai Sun,

Pankaj Bhavsar,

Matthew Loza,

Frederic Baribaud,

Pascal Chanez,

Stephen J Fowler,

Ildiko Horvath,

Paolo Montuschi,

Florian Singer,

Jacek Musial,

Barbro Dahlen,

Norbert Krug,

Thomas Sandstrom,

Dominic E Shaw,

Rene Lutter,

Louise J Fleming,

Peter H Howarth,

Massimo Caruso,

Ana R Sousa,

Julie Corfield,

Charles Auffray,

Bertrand De Meulder,

Diane Lefaudeux,

Sven-Erik Dahlen,

Ratko Djukanovic,

Peter J Sterk,

Yike Guo,

Ian M Adcock,

& Kian Fan Chung

, 2022 , Clinical and Translational Medicine , 12 (4) , e816

DOI: 10.1002/ctm2.816

Type: article

Altered regulation of BRCA1 exon 11 splicing is associated with breast cancer risk in carriers of BRCA1 pathogenic variants

Gorka Ruiz De Garibay,

Ignacio Fernandez‐garcia,

Sylvie Mazoyer,

Flavia Leme De Calais,

Pietro Ameri,

Sangeeta Haydeliz Martinez‐ruiz,

Francesca Damiola,

Laure Barjhoux,

Mads Thomassen,

Lars V. B. Andersen,

Carmen Herranz,

Francesca Mateo,

Luis Palomero,

Roderic Espin,

Antonio Gómez,

Nadia García,

Daniel Jimenez,

Núria Bonifaci,

Ana I. Extremera,

Julio Castaño,

Angel Raya,

Eduardo Eyras,

Xose S. Puente,

Joan Brunet,

Conxi Lázaro,

Gemo,

Cimba,

Paolo Radice,

Daniel R. Barnes,

Antonis C. Antoniou,

Amanda B. Spurdle,

Miguel Hoya,

Diana Baralle,

Mary Helen Barcellos‐hoff,

& Miquel A. Pujana

, 2021 , Human Mutation , 42 (11) , 1488--1502

DOI: 10.1002/humu.24276

Type: article

The immunopeptidomes of two transmissible cancers and their host have a common, dominant peptide motif

A Gastaldello,

S H Ramarathinam,

A Bailey,

R Owen,

S Turner,

A Kontouli,

T Elliott,

P Skipp,

A W Purcell,

& H V Siddle

, 2021 , Immunology , 163 (2) , 169--184

DOI: 10.1111/imm.13307

Type: article

A novel ACE2 isoform is expressed in human respiratory epithelia and is upregulated in response to interferons and RNA respiratory virus infection

Cornelia Blume,

Claire L. Jackson,

Cosma Mirella Spalluto,

Jelmer Legebeke,

Liliya Nazlamova,

Franco Conforti,

Jeanne Marie Perotin,

Martin Frank,

John Butler,

Max Crispin,

Janice Coles,

James Thompson,

Robert A. Ridley,

Lareb S.N. Dean,

Matthew Loxham,

Stephanie Reikine,

Adnan Azim,

Kamran Tariq,

David A. Johnston,

Paul J. Skipp,

Ratko Djukanovic,

Diana Baralle,

Christopher J. McCormick,

Donna E. Davies,

Jane S. Lucas,

Gabrielle Wheway,

& Vito Mennella

, 2021 , Nature Genetics , 53 (2) , 205--214

DOI: 10.1101/2020.07.31.230870

Type: article

Ileal transcriptomic analysis in paediatric Crohn's disease reveals IL17- and NOD-signalling expression signatures in treatment-naïve patients and identifies epithelial cells driving differentially expressed genes

James John Ashton,

Konstantinos Boukas,

James David Davies,

Imogen Sian Stafford,

Andres Vallejo,

Rachel Haggarty,

Tracy Antonio Francisco Coelho,

Akshay Batra,

Nadeem A. Afzal,

Bhumita Vadgama,

Anthony Williams,

R. Mark Beattie,

Marta Polak,

& Sarah Ennis

, 2020 , Journal of Crohn's and Colitis , 15 (5) , 774--786

DOI: 10.1093/ecco-jcc/jjaa236

Type: article

Targeted inhibition of gut bacterial β-glucuronidase activity enhances anticancer drug efficacy

Aadra P Bhatt,

Samuel J. Pellock,

Kristen A. Biernat,

William G. Walton,

Bret D. Wallace,

Benjamin C Creekmore,

Marine M. Letertre,

Jonathan R. Swann,

Ian D. Wilson,

Jose R. Roques,

David B. Darr,

Sean T. Bailey,

Stephanie A. Montgomery,

Jeffrey M. Roach,

M. Andrea Azcarate-Peril,

R. Balfour Sartor,

Raad Z. Gharaibeh,

Scott J. Bultman,

& Matthew R. Redinbo

, 2020 , Proceedings of the National Academy of Sciences , 117 (13) , 7374--7381

DOI: 10.1073/pnas.1918095117

Type: article

Alvaro A. Cruz,

John H. Riley,

Aruna T. Bansal,

Eduardo V. Ponte,

Adelmir Souza-Machado,

Paula C.A. Almeida,

Valmar Biao-Lima,

Maggie Davis,

Stewart Bates,

Ian M. Adcock,

Peter J. Sterk,

Kian Fan Chung,

James Schofield,

& Paul Skipp

, 2020 , Respiratory Medicine , 161 , 1--8

DOI: 10.1016/j.rmed.2019.105817

Type: article