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Research project

Dr P. Elkington: Investigating multi-drug resistant tuberculosis in the 3-dimensional bioelectrospray cell culture model

Project overview

We will develop luminescent strains of multi-drug resistant tuberculosis and investigate the response to antibiotics in our biomimetic model system.

Staff

Lead researcher

Professor Paul Elkington

Director of Inst. for Medical Innovation

Research interests

  • tuberculosis
  • immunopathology
  • diagnosis

Research outputs

Dissection of the host-pathogen interaction in human tuberculosis using a bioengineered 3-dimensional model
Liku B. Tezera,
Magdalena Bielecka,
Andrew Chancellor,
Michaela Reichmann,
Basim Al Shammari,
Patience Brace,
Alex Batty,
Annie Tocheva,
Sanjay Jogai,
Ben G. Marshall,
Marc Tebruegge,
Suwan N. Jayasinghe,
Salah Mansour,
& Paul Elkington
, 2017 , eLife , 6
DOI: 10.7554/eLife.21283
Type: article
CD1b-restricted GEM T cell responses are modulated by Mycobacterium tuberculosis mycolic acid meromycolate chains
Andrew Chancellor,
Anna Tocheva,
Christopher Cave-Ayland,
Liku Bekele Tezera,
Andrew White,
Juma'a Al Dulayymi,
John Bridgeman,
Ivo Tews,
Susan Wilson,
Nikolai Lissin,
Marc Tebruegge,
Benjamin Marshall,
Sally Sharpe,
Timothy Elliott,
Chris-Kriton Skylaris,
Jonathan W. Essex,
Mark Baird,
Stephan D. Gadola,
Paul Elkington,
& Salah Mansour
, 2017 , Proceedings of the National Academy of Sciences , 114 (51) , E10956--E10964
DOI: 10.1073/pnas.1708252114
Type: article
Tuberculosis: an infection-initiated autoimmune disease?
Paul Elkington,
Marc Tebruegge,
& Salah Mansour
, 2016 , Trends in Immunology , 37 (12) , 815--818
DOI: 10.1016/j.it.2016.09.007
Type: article