Research Research groups Member of: Cancer Sciences Research projects Active projects Defining The Tumour Microenvironment Of Recurrant Gastrointestinal Stromal Tumours (GIST) To Identify Novel Therapeutic Strategies Researchers: Doctor Zoë Walters , Professor Tim Underwood , Doctor Benjamin Sharpe , Mr Oliver Pickering Sponsor: Sarcoma UK Completed projects Investigating the cellular microenvironment of lymph node metastasis in oesophageal adenocarcinoma Researchers: Professor Tim Underwood , Doctor Benjamin Sharpe Sponsor: Guts UK Publications 3 publications Page 1 of 1 Phosphodiesterase type 5 inhibitors enhance chemotherapy in preclinical models of esophageal adenocarcinoma by targeting cancer-associated fibroblasts Benjamin P Sharpe, Annette Hayden, Antigoni Manousopoulou, Andrew Cowie, Robert C Walker, Jack Harrington, Fereshteh Izadi, Stella P Breininger, Jane Gibson, Oliver Pickering, Eleanor Jaynes, Ewan Kyle, John H Saunders, Simon L Parsons, Alison A Ritchie, Philip A Clarke, Pamela Collier, Nigel P Mongan, David O Bates, Kiren Yacqub-Usman, Spiros D Garbis, Zoë Walters, Matthew Rose-Zerilli, Anna M Grabowska, & Timothy J Underwood , 2022 , Cell Reports Medicine , 3 (6) , 100541 DOI: 10.1016/j.xcrm.2022.100541 Type: article Digital pathology and machine learning for prediction of response to neoadjuvant chemotherapy in oesophageal adenocarcinoma B. Sharpe, S. Rahman, J. Early, G. Vigneswaran, J. Horne, B. Grace, J. West, Z. Walters, S. Ramchurn, & T. Underwood , 2021 , The Journal of Pathology , 255 , S35 Type: conference Genomic analysis of response to neoadjuvant chemotherapy in esophageal adenocarcinoma , Fereshteh Izadi, Benjamin P. Sharpe, Stella P. Breininger, Maria Secrier, Jane Gibson, Robert C. Walker, Saqib Rahman, Ginny Devonshire, Megan A. Lloyd, Zoë S. Walters, Rebecca C. Fitzgerald, Matthew J.J. Rose-Zerilli, & Tim J. Underwood , 2021 , Cancers , 13 (14) DOI: 10.3390/cancers13143394 Type: article