Jane Gibson

Research

Research groups

Member of:

Research projects

Active projects

Evaluating the efficacy of Enhancer of Zeste Homolog 2 (EZH2) inhibitors in combination with anti-GD2/isotretinoin for the treatment of high-risk neuroblastoma: a pre-clinical study

Researchers:

Doctor Zoë Walters

Doctor Juliet Gray ,

Doctor Jane Gibson

Sponsor: Childrens Cancer and Leukaemia Group

Identifying the underlying molecular mechanisms and alterations of the high-risk neuroblastoma tumour microenvironment in TH-MYCN mice treated with anti-GD2 antibody therapy

Researchers:

Doctor Juliet Gray ,

Doctor Jane Gibson ,

Doctor Zoë Walters

Sponsor: Wessex Medical Research

Microfluidic Platelet Profiling: Linking Platelet Reactivity With Molecular Signatures For Thrombosis Risk Prediction

Researchers:

Doctor Jonathan West

Doctor Nicola Englyst ,

Doctor Jane Gibson ,

Professor Diana Baralle

Sponsor: British Heart Foundation

Completed projects

A Lotery: Molecular genetics study to identify novel genetic variants for Primary Open Angle Glaucoma

Researchers:

Professor Andrew Lotery

Professor Sarah Ennis ,

Doctor Jane Gibson

Sponsor: International Glaucoma Association

Publications

70 publications

Page 1 of 7

Phosphodiesterase type 5 inhibitors enhance chemotherapy in preclinical models of esophageal adenocarcinoma by targeting cancer-associated fibroblasts

Benjamin P Sharpe,

Annette Hayden,

Antigoni Manousopoulou,

Andrew Cowie,

Robert C Walker,

Jack Harrington,

Fereshteh Izadi,

Stella P Breininger,

Jane Gibson,

Oliver Pickering,

Eleanor Jaynes,

Ewan Kyle,

John H Saunders,

Simon L Parsons,

Alison A Ritchie,

Philip A Clarke,

Pamela Collier,

Nigel P Mongan,

David O Bates,

Kiren Yacqub-Usman,

Spiros D Garbis,

Zoë Walters,

Matthew Rose-Zerilli,

Anna M Grabowska,

& Timothy J Underwood

, 2022 , Cell Reports Medicine , 3 (6) , 100541

DOI: 10.1016/j.xcrm.2022.100541

Type: article

Pathogenic KDM5B variants in the context of developmental disorders

Jack Harrington,

Gabrielle Wheway,

Sandrine Willaime-Morawek,

Jane Gibson,

& Zoë S Walters

, 2022 , Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms , 1865 (5)

DOI: 10.1016/j.bbagrm.2022.194848

Type: review

The association between serum lipids and intraocular pressure in 2 large United Kingdom cohorts

Kian M. Madjedi,

Kelsey V. Stuart,

Sharon Y.L. Chua,

Robert N. Luben,

Alasdair Warwick,

Louis R. Pasquale,

Jae H. Kang,

Janey L. Wiggs,

Marleen A.H. Lentjes,

Hugues Aschard,

Naveed Sattar,

Paul J. Foster,

Anthony P. Khawaja,

Mark Chia,

Ron Do,

Alan Kastner,

Jihye Kim,

Giovanni Montesano,

Denize Atan,

Tariq Aslam,

Sarah A. Barman,

Jenny H. Barrett,

Paul Bishop,

Peter Blows,

Catey Bunce,

Roxana O. Carare,

Usha Chakravarthy,

Michelle Chan,

David P. Crabb,

Philippa M. Cumberland,

Alexander Day,

Parul Desai,

Bal Dhillon,

Andrew D. Dick,

Cathy Egan,

Sarah Ennis,

Paul Foster,

Marcus Fruttiger,

John E.J. Gallacher,

David F. Garway-Heath,

Jane Gibson,

Dan Gore,

Jeremy A. Guggenheim,

Chris J. Hammond,

Alison Hardcastle,

Simon P. Harding,

Andrew J. Lotery,

James E. Morgan,

Jay Self,

& Irene Stratton

, 2022 , Ophthalmology , 129 (9) , 986--996

DOI: 10.1016/j.ophtha.2022.04.023

Type: article

The (epi)genomic landscape of splenic marginal zone lymphoma: biological implications, clinical utility, and future questions

Carolina Jaramillo Oquendo,

Helen Parker,

David Oscier,

Sarah Ennis,

Jane Gibson,

& Jonathan Strefford

, 2021 , Journal of Translational Genetics and Genomics

DOI: 10.20517/jtgg.2021.04

Type: review

Genomic analysis of response to neoadjuvant chemotherapy in esophageal adenocarcinoma

Fereshteh Izadi,

Benjamin P. Sharpe,

Stella P. Breininger,

Maria Secrier,

Jane Gibson,

Robert C. Walker,

Saqib Rahman,

Ginny Devonshire,

Megan A. Lloyd,

Zoë S. Walters,

Rebecca C. Fitzgerald,

Matthew J.J. Rose-Zerilli,

& Tim J. Underwood

, 2021 , Cancers , 13 (14)

DOI: 10.3390/cancers13143394

Type: article

Retinal asymmetry in multiple sclerosis

Axel Petzold,

Sharon Y.L. Chua,

Anthony P. Khawaja,

Pearse A. Keane,

Peng T. Khaw,

Charles Reisman,

Baljean Dhillon,

Nicholas G. Strouthidis,

Paul J. Foster,

Praveen Patel,

Denize Atan,

Tariq Aslam,

Sarah A. Barman,

Jenny H. Barrett,

Paul Bishop,

Catey Bunce,

Roxana O. Carare,

Usha Chakravarthy,

Michelle Chan,

Sharon Y.L. Chua,

David P. Crabb,

Alexander Day,

Parul Desai,

Bal Dhillon,

Andrew D. Dick,

Cathy Egan,

Sarah Ennis,

Paul J. Foster,

Marcus Fruttiger,

John E.J. Gallacher,

David F. Garway-Heath,

Jane Gibson,

Dan Gore,

Jeremy A. Guggenheim,

Chris J. Hammond,

Alison Hardcastle,

Simon P. Harding,

Ruth E. Hogg,

Pirro Hysi,

Pearse A. Keane,

Sir Peng T. Khaw,

Anthony P. Khawaja,

Gerassimos Lascaratos,

Andrew J. Lotery,

Tom MacGillivray,

Sarah MacKie,

Michelle McGaughey,

James E. Morgan,

Jay Self,

& Irene Stratton

, 2021 , Brain , 144 (1) , 224--235

DOI: 10.1093/brain/awaa361

Type: article

Investigation of associations between retinal microvascular parameters and albuminuria in UK Biobank

Euan N. Paterson,

Chris Cardwell,

Thomas J. MacGillivray,

Emanuele Trucco,

Alexander S. Doney,

Paul Foster,

Alexander P. Maxwell,

Gareth McKay,

Tariq Aslam,

Sarah Barman,

Jenny Barrett,

Paul Bishop,

Peter Blows,

Catey Bunce,

Roxana Carare,

Usha Chakravarthy,

Michelle Chan,

Antonietta Chianca,

Valentina Cipriani,

David Crabb,

Philippa Cumberland,

Alexander Day,

Parul Desai,

Bal Dhillon,

Andrew Dick,

Cathy Egan,

Sarah Ennis,

Marcus Fruttiger,

John Gallacher,

David (Ted) Garway-Heath,

Jane Gibson,

Dan Gore,

Jeremy Guggenheim,

Chris Hammond,

Alison Hardcastle,

Simon Harding,

Ruth Hogg,

Pirro Hysi,

Pearse A. Keane,

Sir Peng Tee Khaw,

Anthony Khawaja,

Gerassimos Lascaratos,

Andrew Lotery,

Phil Luthert,

Tom MacGillivray,

Sarah Mackie,

Keith Martin,

James Morgan,

Jay Self,

& Irene Stratton

, 2021 , BMC Nephrology , 22 (1) , 72

DOI: 10.1186/s12882-021-02273-6

Type: article

Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries

Puya Gharahkhani,

Eric Jorgenson,

Pirro Hysi,

Anthony P. Khawaja,

Sarah Pendergrass,

Xikun Han,

Jue Sheng Ong,

Alex W. Hewitt,

Ayellet V. Segrè,

John M. Rouhana,

Andrew R. Hamel,

Robert P. Igo,

Helene Choquet,

Ayub Qassim,

Navya S. Josyula,

Jessica N. Cooke Bailey,

Pieter W.M. Bonnemaijer,

Adriana Iglesias,

Owen M. Siggs,

Terri L. Young,

Veronique Vitart,

Alberta A.H.J. Thiadens,

Juha Karjalainen,

Steffen Uebe,

Ronald B. Melles,

K. Saidas Nair,

Robert Luben,

Mark Simcoe,

Nishani Amersinghe,

Angela J. Cree,

Rene Hohn,

Alicia Poplawski,

Li Jia Chen,

Shi Song Rong,

Tin Aung,

Sarah Martin,

Andrew J. White,

Roxana Carare,

Sarah Ennis,

Paul Foster,

Jane Gibson,

Andrew J. Lotery,

James E. Morgan,

Jay Self,

Irene Stratton,

Xin Wang,

Nicholas G. Martin,

James E. Morgan,

Andrew J. Lotery,

& Ching Yu Cheng

, 2021 , Nature Communications , 12 (1)

DOI: 10.1038/s41467-020-20851-4

Type: article

Genome-wide association meta-analysis of corneal curvature identifies novel loci and shared genetic influences across axial length and refractive error

Qiao Fan,

Alfred Pozarickij,

Nicholas Y.Q. Tan,

Xiaobo Guo,

Virginie J.M. Verhoeven,

Veronique Vitart,

Jeremy A. Guggenheim,

Masahiro Miyake,

J. Willem L. Tideman,

Anthony P. Khawaja,

Liang Zhang,

Stuart MacGregor,

René Höhn,

Peng Chen,

Ginevra Biino,

Juho Wedenoja,

Seyed Ehsan Saffari,

Milly S. Tedja,

Jing Xie,

Carla Lanca,

Ya Xing Wang,

Srujana Sahebjada,

Johanna Mazur,

Alireza Mirshahi,

Nicholas G. Martin,

Seyhan Yazar,

Craig E. Pennell,

Maurice Yap,

Annechien E.G. Haarman,

Clair A. Enthoven,

Jan Roelof Polling,

Joan E. Bailey-Wilson,

Amutha Barathi Veluchamy,

Kathryn P. Burdon,

Harry Campbell,

Li Jia Chen,

Emily Y. Chew,

Jamie E. Craig,

Phillippa M. Cumberland,

David M. Evans,

Qing Li,

James F. Wilson,

Roxana O. Carare,

Sarah Ennis,

Jane Gibson,

Andrew J. Lotery,

James E. Morgan,

Jay Self,

Paul J. Foster,

& Ching Yu Cheng

, 2020 , Communications Biology , 3 (1)

DOI: 10.1038/s42003-020-0802-y

Type: article

A small gene sequencing panel realises a high diagnostic rate in patients with congenital nystagmus following basic phenotyping

Luke O'Gorman,

Chelsea Norman,

Luke Michaels,

Tutte Newall,

Andrew H. Crosby,

Christopher Mattocks,

Angela Cree,

Andrew Lotery,

Emma L. Baple,

Arjuna Ratnayaka,

Diana Baralle,

Helena Lee,

Daniel Osborne,

Fatima Shawkat,

Jane Gibson,

Sarah Ennis,

& Jay E. Self

, 2019 , Scientific Reports , 9 (1)

DOI: 10.1038/s41598-019-49368-7

Type: article

Doctor Jane Gibson

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Active projects

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