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Doctor Jonathan Swann

Dr Jonathan Swann

Professor of Biomolecular Medicine

Accepting applications from PhD students.

Connect with Jonathan

Email: J.Swann@soton.ac.uk

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Research

Research groups

Member of:

Research projects

Active projects

Investigating the influence of gut microbial metabolism on normal age-related cognitive decline

Researchers:

Doctor Jonathan Swann

Sponsor: Biotechnology & Biological Sciences Research Council

Interactions of dietary protein intake and intestinal resident microbiota affecting susceptibility to persistent Giardia infection and Giardia mediated enteropathy

Researchers:

Doctor Jonathan Swann

Sponsor: University of North Carolina at Chapel Hill

NEURODEVELOPMENT IN HIV-EXPOSED UNINFECTED CHILDREN IN RURAL ZIMBABWE

Researchers:

Doctor Jonathan Swann

Sponsor: Medical Research Council

UK Gut-Immunology-Brain Axis Network+ (GIBA)

Researchers:

Doctor Jonathan Swann

Professor Jessica Teeling

Musculoskeletal functional ability in three diverse Sub-Saharan Africa Populations: Prevalence, Nutritional Risk Factors and Implementable Solutions for better muscle health

Researchers:

Professor Kate Ward

Doctor Jonathan Swann

Sponsor: Medical Research Council

Understanding How Food And Beverages Deliver Improved Nutrition Across The Life-course - Diet And Health Open Innovation Research Club (OIRC)

Researchers:

Professor Philip Calder

Doctor Jonathan Swann

Sponsor: Biotechnology & Biological Sciences Research Council

Does Pregnancy Vitamin D Supplementation Alter Trajectories Of Body Composition And Bone Mineralisation From Early Childhood To Adolescence? Follow-up Of A Randomised Placebo-controlled Trial

Researchers:

Doctor Rebecca Moon

Professor Cyrus Cooper ,

Professor Nicholas Harvey ,

Doctor Elizabeth Curtis ,

Professor Kate Ward ,

Doctor Jonathan Swann

Sponsor: Action Medical Research

ETHEREAL - Horizon Europe (UKRI funded)

Researchers:

Professor Koushik Maharatna

Professor James Batchelor ,

Professor Paolo Rapisarda ,

Professor Konstantinos Katsikopoulos ,

Professor Samuele Cortese ,

Doctor Jonathan Swann

Sponsor: UKRI (Research England) - EU Horizon guarantee Scheme

Understanding The Impact Of Multi-locus Imprinting Disturbance On Clinical Outcomes In Imprinting Disorders

Researchers:

Professor Deborah Mackay

Doctor Jonathan Swann

Sponsor: Medical Research Council

Horizon Europe - PUREMIND - PERSONAL NATURAL ENVIRONMENT-GENE-GUT-BRAIN INTERACTIONS BASED ECOSYSTEM FOR PREVENTION OF MENTAL ILLNESS IN CHILDREN, ADOLESCENTS AND YOUNG ADULTS (PUREMIND)

Researchers:

Professor Koushik Maharatna

Professor James Batchelor ,

Professor Michael Boniface ,

Professor Paolo Rapisarda ,

Professor Mahesan Niranjan ,

Doctor Katherine Bradbury ,

Doctor Jonathan Swann ,

Doctor Ernesto Elias Vidal Rosas ,

Professor Samuele Cortese

Assessment of mitochondrial capacity in patients with post-acute COVID syndrome

Researchers:

Doctor Ahilanandan Dushianthan ,

Professor Mike Grocott

Doctor Paul Afolabi ,

Doctor Colleen Deane ,

Professor Martin Feelisch ,

Doctor Jonathan Swann

Gut-Brain axis in critical illness

Researchers:

Doctor Ahilanandan Dushianthan ,

Doctor Jonathan Swann ,

Professor David Baldwin ,

Doctor Franklin Nobrega

Defining molecular mechanisms and endophenotypes of hospitalised patients with acute respiratory failure from severe pneumonia: A bench to bedside pilot study

Researchers:

Doctor Ahilanandan Dushianthan

Professor Martin Feelisch ,

Doctor Kordo Saeed ,

Professor Tom Wilkinson ,

Doctor Jonathan Swann ,

Professor Senthil Murugan Ganapathy ,

Professor Mike Grocott

Lung Lipidomic Analysis

Researchers:

Doctor Ahilanandan Dushianthan ,

Professor Senthil Murugan Ganapathy ,

Professor Mike Grocott

Doctor Jonathan Swann

Climate, muscle function and metabolomics

Researchers:

Professor Kate Ward

Doctor Jonathan Swann

Holistic Optical Biomarkers for Early Differential Dementia Diagnosis (HOpE)

Researchers:

Professor Sumeet Mahajan

Professor Roxi Carare ,

Professor Amritpal Mudher ,

Professor Jessica Teeling ,

Professor Mahesan Niranjan ,

Doctor Jonathan Swann ,

Mr Rami Salib

Completed projects

Gastrointestinal metabolomics

Researchers:

Doctor Jonathan Swann

Sponsor: Mayo Clinic

CHAIN Consortium $78,251 USD

Researchers:

Doctor Jonathan Swann

Sponsor: Bill & Melinda Gates Foundation

ELICIT - retrospective costing - Jonathan Swann

Researchers:

Doctor Jonathan Swann

Sponsor: Bill & Melinda Gates Foundation

Microbiota On Osteoarthritis

Researchers:

Doctor Jonathan Swann

Sponsor: Medical Research Council

Determining the role of the metabolome on amyloid deposition in proteinopathies

Researchers:

Professor Phil Williamson ,

Professor Amritpal Mudher ,

Doctor Jonathan Swann

CHild malnutrition & Adult NCD: Generating Evidence on mechanistic links to inform future policy/practice (CHANGE project)

Researchers:

Doctor Jonathan Swann

Sponsor: Medical Research Council

Characterising the impact of the gut microbiota and their metabolites on tau phenotypes in a Drosophila model

Researchers:

Doctor Jonathan Swann

Sponsor: Alzheimers Research UK

Alanyl-glutamine supplementation of standard treatment for C. difficile infection

Researchers:

Doctor Jonathan Swann

Sponsor: National Institutes of Health

Metabolic characterisation of critically ill patients: an observational study focusing on mitochondria

Researchers:

Doctor Ahilanandan Dushianthan

Doctor Paul Afolabi ,

Doctor Jonathan Swann ,

Professor Philip Calder ,

Doctor Colleen Deane ,

Mr Paul Muckelt ,

Professor Pete Worsley ,

Professor Martin Feelisch ,

Professor Mike Grocott

Biography

Jonathan Swann is a Professor of Biomolecular Medicine within the School of Human Development and Health in the Faculty of Medicine. He is responsible for leading a metabolomics-based research programme to understand the influence of gene-environment interactions on the mammalian metabolic system and their implications for health and disease. His primary research interests fall under two intersecting research themes:

(1) Role of the gut microbiota (the collection of microbes residing in the gastrointestinal tract) in the mammalian supra-organism and their influence on host health and disease. This includes the biomolecular communication between these systems, the microbial contribution to host endogenous and xenobiotic metabolism, the gut-brain axis and its role in neurological disorders, the carcinogenic potential of the microbiome, and the environmental and host factors that shape the acquisition and composition of the gut microbiome.

(2) Impact of early-life events and exposures on human development particularly microbial-host interplay, metabolism, and phenotypic outcomes. A key research area is the application of metabolic phenotyping to the field of global health. Specifically, using a metabolomic approach to characterise the biochemical consequences of undernutrition and infection in children from developing countries to better understand the contributors to adverse later life outcomes. This includes impaired growth, cognitive, and metabolic functions.

Prof Swann’s research is supported by the BBSRC, MRC, Wellcome Trust, Bill and Melinda Gates Foundation, National Institutes of Health (NIH), Danone, and Optibiotix. He is a visiting professor in the Department of Metabolism, Digestion and Reproduction at Imperial College London and a visiting academic in the Department of Neuroscience at the Karolinska Institute, Sweden. He is on the editorial board for the journals Microbiome, and Frontiers in Endocrinology, and sits on numerous expert panels relating to the gut microbiota including the British Society of Gastroenterology – Gut Microbiota for Health expert panel.

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