Doctor Jonathan Swann

Dr Jonathan Swann

Professor of Biomolecular Medicine

Accepting applications from PhD students.

Connect with Jonathan

Email: j.swann@soton.ac.uk

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Research

Research groups

Member of:

Research projects

Active projects

Investigating the influence of gut microbial metabolism on normal age-related cognitive decline

Researchers:

Doctor Jonathan Swann

Sponsor: Biotechnology & Biological Sciences Research Council

Microbiota On Osteoarthritis

Researchers:

Doctor Jonathan Swann

Sponsor: Medical Research Council

CHild malnutrition & Adult NCD: Generating Evidence on mechanistic links to inform future policy/practice (CHANGE project)

Researchers:

Doctor Jonathan Swann

Sponsor: Medical Research Council

Interactions of dietary protein intake and intestinal resident microbiota affecting susceptibility to persistent Giardia infection and Giardia mediated enteropathy

Researchers:

Doctor Jonathan Swann

Sponsor: University of North Carolina at Chapel Hill

NEURODEVELOPMENT IN HIV-EXPOSED UNINFECTED CHILDREN IN RURAL ZIMBABWE

Researchers:

Doctor Jonathan Swann

Sponsor: Medical Research Council

Musculoskeletal functional ability in three diverse Sub-Saharan Africa Populations: Prevalence, Nutritional Risk Factors and Implementable Solutions for better muscle health

Researchers:

Professor Kate Ward

,

Professor Cyrus Cooper ,

Doctor Jonathan Swann

Sponsor: Medical Research Council

Understanding How Food And Beverages Deliver Improved Nutrition Across The Life-course - Diet And Health Open Innovation Research Club (OIRC)

Researchers:

Professor Philip Calder

,

Doctor Jonathan Swann

Sponsor: Biotechnology & Biological Sciences Research Council

Does Pregnancy Vitamin D Supplementation Alter Trajectories Of Body Composition And Bone Mineralisation From Early Childhood To Adolescence? Follow-up Of A Randomised Placebo-controlled Trial

Researchers:

Doctor Rebecca Moon

,

Professor Cyrus Cooper ,

Professor Nicholas Harvey ,

Professor Kate Ward ,

Doctor Jonathan Swann

Sponsor: Action Medical Research

Understanding The Impact Of Multi-locus Imprinting Disturbance On Clinical Outcomes In Imprinting Disorders

Researchers:

Professor Deborah Mackay

,

Doctor Jonathan Swann

Sponsor: Medical Research Council

NIHR BRC bid from December 2022

Researchers:

Professor Mike Grocott

,

Dame Wendy Hall ,

Professor Keith Godfrey ,

Professor Graham Roberts ,

Professor Saul Faust ,

Professor Tom Wilkinson ,

Professor Robert Read ,

Professor Age Chapman ,

Doctor Jonathan Swann

Sponsor: National Institute of Health and Care Research

Completed projects

Gastrointestinal metabolomics

Researchers:

Doctor Jonathan Swann

Sponsor: Mayo Clinic

CHAIN Consortium $78,251 USD

Researchers:

Doctor Jonathan Swann

Sponsor: Bill & Melinda Gates Foundation

ELICIT - retrospective costing - Jonathan Swann

Researchers:

Doctor Jonathan Swann

Sponsor: Bill & Melinda Gates Foundation

Characterising the impact of the gut microbiota and their metabolites on tau phenotypes in a Drosophila model

Researchers:

Doctor Jonathan Swann

Sponsor: Alzheimers Research UK

Biography

Jonathan Swann is a Professor of Biomolecular Medicine within the School of Human Development and Health in the Faculty of Medicine. He is responsible for leading a metabolomics-based research programme to understand the influence of gene-environment interactions on the mammalian metabolic system and their implications for health and disease. His primary research interests fall under two intersecting research themes:

(1) Role of the gut microbiota (the collection of microbes residing in the gastrointestinal tract) in the mammalian supra-organism and their influence on host health and disease. This includes the biomolecular communication between these systems, the microbial contribution to host endogenous and xenobiotic metabolism, the gut-brain axis and its role in neurological disorders, the carcinogenic potential of the microbiome, and the environmental and host factors that shape the acquisition and composition of the gut microbiome.

(2) Impact of early-life events and exposures on human development particularly microbial-host interplay, metabolism, and phenotypic outcomes. A key research area is the application of metabolic phenotyping to the field of global health. Specifically, using a metabolomic approach to characterise the biochemical consequences of undernutrition and infection in children from developing countries to better understand the contributors to adverse later life outcomes. This includes impaired growth, cognitive, and metabolic functions.

Prof Swann’s research is supported by the BBSRC, MRC, Wellcome Trust, Bill and Melinda Gates Foundation, National Institutes of Health (NIH), Danone, and Optibiotix. He is a visiting professor in the Department of Metabolism, Digestion and Reproduction at Imperial College London and a visiting academic in the Department of Neuroscience at the Karolinska Institute, Sweden. He is on the editorial board for the journals Microbiome, and Frontiers in Endocrinology, and sits on numerous expert panels relating to the gut microbiota including the British Society of Gastroenterology – Gut Microbiota for Health expert panel.

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