Open menu
View all research projects
Research project

Defining the role of ZEB1-dependent epithelial-mesenchymal crosstalk in lung fibrosis

  • Research groups:
  • Lead researcher:
    Dr Yihua Wang
  • Research funder:
    Medical Research Council
  • Status:
    Not active

Project overview

Idiopathic pulmonary fibrosis (IPF) is a life-threatening condition of the lungs where tissue becomes thickened, stiff, and scarred, limiting the amount of oxygen getting into the blood. The aim of this project is to provide effective targeted therapies for sufferers to reduce symptoms of this devastating disease and improve their quality of life as well as to identify biomarkers for IPF patients.

Staff

Lead researcher

Dr Yihua Wang

Associate Professor

Research interests

  • Cell Signalling in Disease
  • Epithelial-Mesenchymal Crosstalk
  • Pulmonary Fibrosis

Collaborating research institutes, centres and groups

Cell and Developmental Biology

We explore how molecular interactions between proteins and small molecules, defined at atomic resolution, govern biochemical output and in turn control cell behaviour.

Research outputs

Risk factors associated with disease severity and length of hospital stay in COVID-19 patients
Xiaofan Liu,
Hong Zhou,
Yilu Zhou,
Xiaojun Wu,
Yang Zhao,
Yang Lu,
Weijun Tan,
Mingli Yuan,
Xuhong Ding,
Jinjing Zou,
Ruiyun Li,
Hailing Liu,
Robert Ewing,
Yi Hu,
Hanxiang Nie,
& Yihua Wang
, 2020 , Journal of Infection , 81 (1) , e95--e97
DOI: 10.1016/j.jinf.2020.04.008
Type: letterEditorial
WDHD1 is essential for the survival of PTEN-inactive triple negative breast cancer
Ayse Ertay,
Huiquan Liu,
Dian Liu,
Ping Peng,
Charlotte Hill,
Hua Xiong,
David Hancock,
Xianglin Yuan,
Marcin Przewloka,
Mark Coldwell,
Michael Howell,
Paul Skipp,
Robert Ewing,
Julian Downward,
& Yihua Wang
, 2020 , Cell Death and Disease
DOI: 10.1038/s41419-020-03210-5
Type: article
Deconvolution of RNA-seq analysis of hyperbaric oxygen-treated mice lungs reveals mesenchymal cell subtype changes
Yuan Yuan,
Yilu Zhou,
Yali Li,
Charlotte Hill,
Robert Ewing,
Mark Jones,
Donna Davies,
Zhenglin Jiang,
& Yihua Wang
, 2020 , International Journal of Molecular Sciences , 21 (4) , 1--19
DOI: 10.3390/ijms21041371
Type: article