Doctor Yihua Wang

Doctor Yihua Wang

Associate Professor

Research interests

Cell Signalling in Disease
Epithelial-Mesenchymal Crosstalk
Pulmonary Fibrosis

Accepting applications from PhD students.

Connect with Yihua

Email: yihua.wang@soton.ac.uk

Address: B85, East Highfield Campus, University Road, SO17 1BJ (View in Google Maps)

Google Scholar

ORCID

LinkedIn

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Research

Research groups

Member of:

Research interests

Cell Signalling in Disease
Epithelial-Mesenchymal Crosstalk
Pulmonary Fibrosis
Precision Oncology

Research projects

Active projects

Defining the role of ZEB1-dependent epithelial-mesenchymal crosstalk in lung fibrosis

Researchers:

Doctor Yihua Wang

Sponsor: Medical Research Council

Factor Inhibiting HIF (FIH) in lung fibroblasts: a determinant of aberrant mesenchymal-epithelial crosstalk?

Researchers:

Doctor Yihua Wang

,

Doctor Mark Jones

Sponsor: Aair Charity

MRF Skills Training And Development Award

Researchers:

Doctor Yihua Wang

Sponsor: Medical Research Foundation

H2020 RIA IMI2-rapiD and secuRe AI imaging based diaGnosis, stratification, fOllow-up, and preparedness for coronavirus paNdemics.-DRAGON

Researchers:

Professor Diana Baralle

,

Professor Ratko Djukanovic ,

Professor Tom Wilkinson ,

Doctor Yihua Wang ,

Doctor Eleanor Seaby

Sponsor: European Union

Preclinical evaluation of potential therapeutic targets (Project 2)

Researchers:

Doctor Mark Jones

,

Professor Donna Davies ,

Doctor Yihua Wang

A 3D molecular atlas of the human lung fibrosis microenvironment

Researchers:

Doctor Mark Jones

,

Professor Donna Davies ,

Professor Gareth Thomas ,

Doctor Yihua Wang

Completed projects

Define the role of MYO9B in pulmonary fibrosis

Researchers:

Doctor Yihua Wang

,

Professor Paul Skipp ,

Doctor Mark Jones ,

Professor Rob Ewing

Sponsor: Royal Society

Role of autophagy in oncogenic RAS-induced invasive behaviour

Researchers:

Doctor Yihua Wang

Sponsor: Royal Society

Controlling oxygen levels to improve models of lung disease - Hypoxia Chamber

Researchers:

Doctor Yihua Wang

,

Doctor Mark Jones

Sponsor: Aair Charity

Defining the role of Factor Inhibiting HIF (FIH) in pulmonary fibrosis

Researchers:

Doctor Yihua Wang

Sponsor: Aair Charity

How does autophagy regulate the development of idiopathic pulmonary fibrosis (IPF)?

Researchers:

Doctor Yihua Wang

Sponsor: Aair Charity

Epithelial-mesenchymal transition (EMT) induced by RAS activation in alveolar Type II cells leads to idiopathic pulmonary fibrosis (IPF) or lung cancer invasion?

Researchers:

Doctor Yihua Wang

Sponsor: Wessex Medical Research

The role of Factor inhibiting HIF (FIH) in the development of idiopathic pulmonary fibrosis (IPF)

Researchers:

Doctor Yihua Wang

Sponsor: The Academy of Medical Sciences

D. Davies - Boehringer Ingelheim - Project 1 IPF target validation

Researchers:

Professor Donna Davies

,

Doctor Mark Jones ,

Doctor Yihua Wang

The interactome of TRPA1 in Idiopathic Pulmonary Fibrotic Lung Fibroblasts

Researchers:

Professor Paul Skipp ,

Doctor Mark Jones ,

Doctor Yihua Wang

Sponsor: Aair Charity

Supervision

Current PhD Students

Beatriz Valdez Moreno

PhD Biological Sciences

Lucy Sayer

iPhD Biomed

Yilu Zhou

PhD Biological Sciences

Zijian Xu

PhD Biological Sciences

Hualong Zhao

PhD Biological Sciences

Siyuan Wang

PhD Biological Sciences

Xi Li

PhD Biological Sciences

Tao Guo

MRes Advanced Biological Sci

Yi Sui

PhD Biological Sciences

Kun Zheng

PhD Biological Sciences

Biography

I have a long-held interest in functional genomics and cell signalling and have published over 80 papers in peer-reviewed journals, including corresponding-authored Lancet Respir Med, eLife, Cell Death Differ, Autophagy, Journal of Infection and Cell Death Dis, and first-authored Nat Cell Biol and PNAS articles etc., with an H index of 33 (Google Scholar).

After successful completion of MBBS in medicine and PhD in cell biology, I undertook postdoctoral training in Julian Downward’s CRUK Signal Transduction laboratory and Prof Xin Lu’s lab in Ludwig Institute for Cancer Research Oxford Branch. In 2016, I joined School of Biological Sciences (BioSci) in the University of Southampton (UoS) as Lecturer after being successful at a very competitive recruitment process. I have sought to identify research links in areas of strategic importance to the University and I recognised that lung diseases offered me this opportunity. My fundamental work on hypoxia, RAS signalling, regulators of epithelial polarity and on epithelial–mesenchymal transition (EMT) is not only crucial for understanding diseases such as cancer, but for many other chronic diseases where epithelial dysfunction and fibrosis are evident. To make my current work distinct and competitive, it was immediately clear that my skills and experience were highly relevant to non-malignant lung disease, especially idiopathic pulmonary fibrosis (IPF), which has a prognosis worse than many cancers. This allowed me to integrate with Southampton's internationally recognised ‘bench to bedside’ researchers in both cancer AND respiratory disease, and to rapidly establish a distinct niche for myself in UoS.

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