Prof R. Read: A genetically modified nasopharyngeal commensal as a platform for human bacteriotherapy

Staff

Lead researchers

Professor Robert Read

Chair of Infectious Diseases

Connect with Robert

Email: R.C.Read@soton.ac.uk

Other researchers

Emeritus Professor Ian Clarke

Research interests

Transposon mutagenesis of Chlamydia species
Cell culture systems and replicons for human noroviruses

Connect with Ian

Email: inc@soton.ac.uk

Professor Saul Faust MBBS, FRCPCH, PhD, FHEA, OBE

Professor Paediatric Immunology & Infect

Connect with Saul

Email: s.faust@soton.ac.uk

Research outputs

Neisseria lactamica controlled human infection model

Adam P. Dale, Diane F. Gbesemete, Robert C. Read & Jay R. Laver, 2022

DOI: 10.1007/978-1-0716-1900-1_21

Type: bookChapter

Safety and immunogenicity of seven COVID-19 vaccines as a third dose (booster) following two doses of ChAdOx1 nCov-19 or BNT162b2 in the UK (COV-BOOST): a blinded, multicentre, randomised, controlled, phase 2 trial

Alasdair P S Munro, Leila Janani, Victoria Cornelius, Parvinder K Aley, Gavin Babbage, David Baxter, et al., Marcin Bula, Katrina Cathie, Krishna Chatterjee, Kate Dodd, Yvanne Enever, Karishma Gokani, Anna L Goodman, Christopher A Green, Linda Harndahl, John Haughney, Alexander Hicks, Agatha A van der Klaauw, Jonathan Kwok, Teresa Lambe, Vincenzo Libri, Martin J Llewelyn, Alastair C McGregor, Angela M Minassian, Patrick Moore, Mehmood Mughal, Yama F Mujadidi, Jennifer Murira, Orod Osanlou, Rostam Osanlou, Daniel R Owens, Mihaela Pacurar, Adrian Palfreeman, Daniel Pan, Tommy Rampling, Karen Regan, Stephen Saich, Jo Salkeld, Dinesh Saralaya, Sunil Sharma, Ray Sheridan, Ann Sturdy, Emma C Thomson, Shirley Todd, Chris Twelves, Robert C Read, Sue Charlton, Bassam Hallis, Mary Ramsay, Nick J. Andrews, Jonathan Nguyen-Van-Tam, Matthew D. Snape, Xinxue Liu & Saul N Faust, 2021, The Lancet, 398(10318), 2258-2276

DOI: 10.1016/S0140-6736(21)02717-3

Type: article

Antibiotics for lower respiratory tract infection in children presenting in primary care in England (ARTIC PC)

Paul Little, Nick A Francis, Beth Stuart, Gilly O'Reilly, Natalie Thompson, Taeko Becque, Alastair D Hay, Kay Wang, Michael Sharland, Anthony Harnden, Guiqing Yao, James Raftery, Shihua Zhu, Joseph Little, Charlotte Hookham, Kate Rowley, Joanne Euden, Kim Harman, Samuel Coenen, Robert C Read, Catherine Woods, Christopher C Butler, Saul N Faust, Geraldine Leydon, Mandy Wan, Kerenza Hood, Jane Whitehurst, Samantha Richards-Hall, Peter Smith, Michael Thomas, Michael Moore & Theo Verheij, 2021, The Lancet, 398(10309), 1417-1426

DOI: 10.1016/S0140-6736(21)01431-8

Type: article

Safety and immunogenicity of heterologous versus homologous prime-boost schedules with an adenoviral vectored and mRNA COVID-19 vaccine (Com-COV): a single-blind, randomised, non-inferiority trial

Xinxue Liu, Robert H. Shaw, Arabella S.V. Stuart, Melanie Greenland, Parvinder K. Aley, Nick J. Andrews, J. Claire Cameron, Sue Charlton, Elizabeth A. Clutterbuck, Andrea M. Collins, Tanya Dinesh, Anna England, Saul N. Faust, Daniela M. Ferreira, Adam Finn, Christopher A. Green, Bassam Hallis, Paul T. Heath, Helen Hill, Teresa Lambe, Rajeka Lazarus, Vincenzo Libri, Fei Long, Yama F. Mujadidi, Emma L. Plested, Samuel Provstgaard-Morys, Maheshi N. Ramasamy, Mary Ramsay, Robert C. Read, Hannah Robinson, Nisha Singh, David P.J. Turner, Paul J. Turner, Laura L. Walker, Rachel White, Jonathan S. Nguyen-Van-Tam, Matthew D. Snape, Alasdair P.S. Munro, Jazz Bartholomew, Laura Presland, Sarah Horswill, Sarah Warren, Sophie Varkonyi-Clifford, Stephen Saich, Kirsty Adams, Marivic Ricamara, Nicola Turner, Nicole Y. Yee Ting, Sarah Whittley & Hannah Sainsbury, 2021, The Lancet, 398(10303), 856-869

DOI: 10.1016/S0140-6736(21)01694-9

Type: article

A recombinant commensal bacteria elicits heterologous antigen-specific immune responses during pharyngeal carriage

Jay R. Laver, Diane Gbesemete, Adam P. Dale, Zoe C. Pounce, Carl N. Webb, Eleanor F. Roche, Graham Berreen, Konstantinos Belogiannis, Alison R. Hill, Muktar M. Ibrahim, David W. Cleary, Anish K. Pandey, Holly E. Humphries, Lauren Allen, Hans de Graaf, Martin C. Maiden, Saul N. Faust, Andrew R. Gorringe & Robert C. Read, 2021, Science Translational Medicine, 13(601)

DOI: 10.1126/scitranslmed.abe8573

Type: article

The infant pharyngeal microbiomes: origin, impact and manipulation

Christine E Jones, Robert Read & Anastasia Theodosiou, 2020, Current Opinion in Infectious Diseases, 33(6), 548-555

DOI: 10.1097/QCO.0000000000000691

Type: article

ACCORD

Tom Wilkinson, Rupert Dixon, Clive Page, Miles Carroll, Gareth Griffiths, Ling-Pei Ho, Anthony De Soyza, Timothy Felton, Keir E Lewis, Karen Phekoo, James D Chalmers, Anthony Gordon, Lorcan McGarvey, Jillian Doherty, Robert C Read, Manu Shankar-Hari, Nuria Martinez-Alier, Michael O'Kelly, Graeme Duncan, Roelize Walles, James Sykes, Charlotte Summers & Dave Singh, 2020, Trials, 21, 691

DOI: 10.1186/s13063-020-04584-9

Type: article