Publications

Explore our research outputs and impact in-depth.

Engineered antibodies to combat viral threats

Mark Cragg,

& Xiaojie Yu

, 2020 , Nature , 588 , 398--399

Type: article

NOX4 inhibition potentiates immunotherapy by overcoming cancer-associated fibroblast-mediated CD8 T-cell exclusion from tumors

K. Ford,

C.J. Hanley,

M. Mellone,

C. Szyndralewiez,

F. Heitz,

P. Wiesel,

O. Wood,

M. Machado,

M.-A. Lopez,

A.-P. Ganesan,

C. Wang,

A. Chakravarthy,

T.R. Fenton,

E.V. King,

P. Vijayanand,

C.H. Ottensmeier,

A. Al-Shamkhani,

N. Savelyeva,

& G.J. Thomas

, 2020 , Cancer Research , 80 (9) , 1846--1860

DOI: 10.1158/0008-5472.CAN-19-3158

Type: article

Pan-AKT Inhibitor Capivasertib With Docetaxel and Prednisolone in Metastatic Castration-Resistant Prostate Cancer

Simon J Crabb,

Gareth Griffiths,

Ellice Marwood,

Denise Dunkley,

Nichola Downs,

Karen Martin,

Michelle Light,

Josh Northey,

Sam Wilding,

Amy Whitehead,

Emily Shaw,

Alison J Birtle,

Amit Bahl,

Tony Elliott,

Charlotte Westbury,

Santhanam Sundar,

Angus Robinson,

Satinder Jagdev,

Satish Kumar,

Claire Rooney,

Carolina Salinas-Souza,

Christine Stephens,

Vincent Khoo,

& Robert J Jones

, 2020 , Journal of Clinical Oncology , JCO2001576

DOI: 10.1200/JCO.20.01576

Type: article

Gene expression profiling in an open-label randomised phase 3 trial (REMoDL-B) of bortezomib added to standard chemoimmunotherapy for diffuse large B-cell lymphoma

Andrew Davies,

Thomas Cummin,

Sharon Barrans,

Tom Maishman,

Christoph Mamot,

Urban Novak,

Joshua Caddy,

Louise Stanton,

Shamim Kazmi-Stokes,

Andrew McMillan,

Paul Fields,

Christopher Pocock,

Graham Collins,

Richard Stephens,

Francesco Cucco,

Alexandra Clipson,

Chulin Sha,

Reuben Tooze,

Matthew A. Care,

Gareth Griffiths,

Ming-Qing Du,

David Westhead,

Catherine Burton,

& Peter Johnson

, 2019 , Lancet Oncology , 20 (5) , 649--662

DOI: 10.1016/S1470-2045(18)30935-5

Type: article

HPV epitope processing differences correlate with ERAP1 allotype and extent of CD8+ T cell tumor infiltration in OPSCC

Emma Reeves,

Oliver Wood,

Christian Ottensmeier,

Emma King,

Gareth Thomas,

Timothy Elliott,

& Edward James

, 2019 , Cancer Immunology Research , 7 (7) , 1202--1213

DOI: 10.1158/2326-6066.CIR-18-0498

Type: article

Resolution limit of image analysis algorithms

Edward A.K. Cohen,

Anish V. Abraham,

Sreevidhya Ramakrishnan,

& Raimund J. Ober

, 2019 , Nature Communications , 10

DOI: 10.1038/s41467-019-08689-x

Type: article

Ibrutinib therapy releases leukemic surface IgM from antigen drive in chronic lymphocytic leukemia patients

Samantha J Drennan,

Giorgia Chiodin,

Annalisa D'Avola,

Ian Tracy,

Peter W. Johnson,

Livio Trentin,

Andrew J. Steele,

Graham Packham,

Freda K. Stevenson,

& Francesco Forconi

, 2019 , Clinical Cancer Research , 25 (8) , 2503--2512

DOI: 10.1158/1078-0432.CCR-18-1286

Type: article

Engineering a HER2-specific antibody–drug conjugate to increase lysosomal delivery and therapeutic efficacy

Jeffrey C. Kang,

Wei Sun,

Priyanka Khare,

Mostafa Karimi,

Xiaoli Wang,

Yang Shen,

R.J. Ober,

& E. Sally Ward

, 2019 , Nature Biotechnology , 37 (5) , 523--526

DOI: 10.1038/s41587-019-0073-7

Type: article

PD-1 blockade and CD27 stimulation activate distinct transcriptional programs that synergize for CD8+ T-cell driven anti-tumor immunity

Sarah Buchan,

Mohannad Fallatah,

Stephen Thirdborough,

Vadim Y. Taraban,

Anne Rogel,

Lawrence J. Thomas,

Christine Penfold,

Li-Zhen He,

Michael Curran,

Tibor Keler,

& Aymen Al-Shamkhani

, 2018 , Clinical Cancer Research , 24 (10) , 2383--2394

DOI: 10.1158/1078-0432.CCR-17-3057

Type: article

The γδTCR combines innate immunity with adaptive immunity by utilizing spatially distinct regions for agonist selection and antigen responsiveness

Daisy Melandri,

Iva Zlatareva,

Raphaël A G Chaleil,

Robin J. Dart,

Andrew Chancellor,

Oliver Nussbaumer,

Oxana Polyakova,

Natalie A. Roberts,

Daniela Wesch,

Dieter Kabelitz,

Peter M. Irving,

Susan John,

Salah Mansour,

Paul A. Bates,

Pierre Vantourout,

& Adrian C. Hayday

, 2018 , Nature Immunology , 19 (12) , 1352–1365

DOI: 10.1038/s41590-018-0253-5

Type: article