lay-summaries-group-2017 | BRAIN UK | University of Southampton

Lay Summaries for all the studies supported by BRAIN UK within the past 12 months.

Please click on the link below to view the individual lay summary.

BRAIN UK Study Ref	Lay Summary	Project Status
22/001	A study of telomere biology in gliomas and drivers of genomic instability	Active
22/002	ATR drives glioma cell invasion via macropinocytic integrin recycling	Active
22/003	Role of microglial subtypes in neurodevelopmental brain diseases	Active
22/004	Validation of Trimethyl Histone H3 (Lys27) Antibody	Active
22/005	Single-cell transcriptomics of prion diseases	Active
22/006	TDP-43 pathology and loss of function in the skeletal muscle	Active
22/007	Alpha-synuclein pathology in metachromatic leukodystrophy	Active
22/009	Understanding the role of the tumour microenvironment in ependymoma tumours	Active
22/010	3D cerebellar models to predict response to novel combination therapy for medulloblastoma with poor prognosis	Active
22/011	Artificial intelligence-based reconstruction of the WHO 2021 diagnostic algorithm for adult-type diffuse gliomas	Active
22/012	The neuropathological examination of patients administered the AN1792 (Aβ42) vaccine	Active
22/013	The New Roads Team – Innovative approaches to curing Brain Tumours	Active
22/014	Development of a cheap sensitive blood test for early detection of new and proven biomarkers of glioblastoma using fluorescent carbon dots and nanophotonics	Active
22/015	Retrospective and prospective analysis of digital images of histology slides of brain tumours using machine learning and deep learning to predict/identify molecular properties	Active
22/016	Elucidating the Tumour Microenvironment of Primary Central Nervous System Lymphoma	Active
22/017	Microglia activation in IDH1 WT glioma is essential for peripheral macrophage recruitment	Active
22/018	New insight into microglial ageing	Active
22/019	Delving deeper into the appearances and pathophysiological mechanisms of immune checkpoint inhibitor-induced hypophysitis	Active
22/020	Targeting the serine synthesis pathway in central nervous system lymphoma	Active
22/021	Multi-modal computational interrogation of the molecular-morphological intersection in brain tumours	Active
22/022	Investigating spontaneous CAA-related inflammation as a model for Aβ immunotherapy-induced side effects (ARIA)	Active
23/002	Juvenile Dermatomyositis Cohort and Biobank Study	Active
23/003	Investigating the genetic basis of nutritional optic and sensory neuropathy in black African and Caribbean communities in the UK	Active

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