BIOL1008 Metabolism & Metabolic Disorders

Learning Outcomes

Learning Outcomes

Having successfully completed this module you will be able to:

• describe the principles of metabolism;
• demonstrate that you have acquired skills in basic biochemical laboratory methods, data interpretation and experimental report writing
• demonstrate an ability to handle simple mathematical treatments of biological processes.
• Having done this course, together with the course on the Molecular basis of life I (BIOL1007), you should be very well-prepared for future work on more complex aspects of biochemistry and molecular biology, and confident and equipped for future work on molecular approaches to physiology, pharmacology, cell biology and biotechnology.
• discuss the role of coenzymes, such as NAD+, FAD and ATP, in metabolism;
• outline the metabolic pathways involved in the catabolism of glucose and fatty acids;
• show how the energy released by catabolism is recouped by substrate level and oxidative phosphorylation;
• show how amino acid and carbohydrate metabolism are inter-linked;
• describe the various types of genetic mutation and inborn errors of metabolism
• describe the methods for detecting and correcting inborn errors of metabolism
• outline the hormonal regulation of metabolism and discuss the role of protein phosphorylation in this context;
• describe the regulation of metabolism in physiological and pathological situations (e.g., exercise, starvation and diabetes);