Skip to main navigationSkip to main content
The University of Southampton
Courses

BIOL2012 Exploring Proteins: Structure and Function

Module Overview

The module will revise and extend the study of protein architecture, interactions and enzyme function. During the module we explain common concepts using specific systems. The case studies include studies of membrane ion channels, enzymes such as proteases, a number of blood proteins including haemoglobin, and antibodies. We also describe how proteomics can be used to characterise and quantitate multiple proteins in parallel, using extremely sensitive analytical techniques, and how this information can be used to obtain clues about the biological roles of proteins.

Aims and Objectives

Learning Outcomes

Learning Outcomes

Having successfully completed this module you will be able to:

  • You will be able to explain the scope and relevance of protein science.
  • You will be able to critically read scientific publications that deal with structural biology and proteomics
  • You will be able to access, use and evaluate the information available in protein databases to find out about a protein of interest
  • You will be able to recognize and describe the architecture of proteins
  • You will be able to relate chemical and physical properties of proteins to their function.
  • You will be able to explain key concepts in protein function such as affinity and specificity, allosteric regulation.
  • Using your new knowledge you will be able to investigate a protein of choice regarding its structure and function as well as its cellular context.
  • You will be able to interpret simple mass spectra of peptides and to derive amino acid sequence information.

Syllabus

The module will revise and extend the study of protein architecture, interactions and enzyme function. During the module we explain common concepts using specific systems. The case studies include studies of membrane ion channels, enzymes such as proteases, a number of blood proteins including haemoglobin, and antibodies. We also describe how proteomics can be used to characterise and quantitate multiple proteins in parallel, using extremely sensitive analytical techniques, and how this information can be used to obtain clues about the biological roles of proteins.

Learning and Teaching

Teaching and learning methods

Lectures, library project and computer questionnaires.

TypeHours
Lecture24
Independent Study122
Tutorial4
Total study time150

Assessment

Summative

MethodPercentage contribution
Computer-based questionnaires 5%
Library project 25%
Written exam  (2 hours) 70%

Referral

MethodPercentage contribution
Coursework 30%
Written exam  (2 hours) 70%

Repeat Information

Repeat type: Internal & External

Linked modules

BIOL1007 AND CHEM1039 OR CHEM1042 OR CHEM1043 OR CHEM1044 OR CHEM1045

Share this module Share this on Facebook Share this on Twitter Share this on Weibo
Privacy Settings