The University of Southampton
Courses

BIOL3014 Molecular Cell Biology

Module Overview

The module will cover protein targeting in eukaryotic cells. This will include trafficking in the ER, Golgi and endosomal pathways as well as protein targeting of nuclear encoded proteins to organelles, such as mitochondria and chloroplasts. In addition, growth factor signalling and how disruption of specific pathways can contribute to disease progression the role of and pathology will be covered. How the mechanical environment in which a cell finds itself could induce signalling events and influence overall cell function will also be examined.

Aims and Objectives

Module Aims

• the ways in which proteins are targeted to their appropriate cellular locations within eukaryotic cells following synthesis; • the mechanisms involved in targeting proteins presented from the external environment; • the role played by growth factors in normal and aberrant cell signaling.

Learning Outcomes

Learning Outcomes

Having successfully completed this module you will be able to:

  • discuss the basic question as to how proteins reach appropriate cellular compartments and what keeps them there
  • outline the roles of rough and smooth endoplasmic reticulum (ER) and discuss the experimental evidence for and the nature of signal sequences in targeting
  • describe the machinery involved in protein translocation at the ER
  • show how proteins synthesised on ER are subsequently sorted and targeted to the appropriate cellular compartment
  • outline the way in which proteins destined for mitochondria and chloroplasts are targeted
  • describe the machinery which is responsible for the translocation and sorting of proteins into mitochondrial compartments
  • provide details of the signaling pathways used growth factors and how the disruption of such pathways can lead to disease.
  • outline how the mechanical environment in which a cell finds itself can induce signalling events and influence overall  cell function

Syllabus

The module will cover protein targeting in eukaryotic cells. This will include trafficking in the ER, Golgi and endosomal pathways as well as protein targeting of nuclear encoded proteins to organelles, such as mitochondria and chloroplasts. In addition, growth factor signalling and how disruption of specific pathways can contribute to disease progression the role of and pathology will be covered. How the mechanical environment in which a cell finds itself could induce signalling events and influence overall cell function will also be examined.

Special Features

N/A

Learning and Teaching

Teaching and learning methods

Lectures and independent study.

TypeHours
Lecture24
Independent Study126
Total study time150

Assessment

Summative

MethodPercentage contribution
Written exam  (2 hours) 100%

Referral

MethodPercentage contribution
Written exam  (2 hours) 100%

Linked modules

Pre-requisites: BIOL2010 Flow Of Genetic Information 2016-17, BIOL2011 Molecular & Cellular Biochemistry 2016-17

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