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The University of Southampton
EngineeringPostgraduate study

SES-74-161 PhD Studentship: Coronary artery stent design for challenging disease

This project seeks to exploit recent advances made in the collaborative efforts between Dr Neil Bressloff (Engineering) and Dr Nick Curzen (Medicine) such that a range of tools developed so far can be extended to better understand issues regularly confronted by interventional cardiologists, with the aim of developing improved forms of treatment for challenging coronary artery disease (CAD).

When attempting to treat CAD by deploying a stent into a diseased vessel, only a standard set of "off-the-shelf" devices are generally available. Thus, the constant and consistent observation that suboptimal deployment of stents is a potent risk factor for both target vessel revascularisation and stent thrombosis, suggests that there is significant scope to develop stents that improve apposition when deployed in challenging anatomy. Current devices can fail to closely follow lumen shape throughout a stented segment leading to unacceptably low lumen area, non-ideal lumen shape and stent malapposition in some regions. Thus, this research project focuses on two key questions: (1) How can the design of coronary stents and their deployment vehicles be improved to achieve far more uniform and consistent stent area in complex coronary anatomy, and (2) Can better conformability and more consistent stent deployment be obtained while maintaining/improving structural integrity, flexibility and stent-artery interaction? The research challenges are to devise novel methods for (i) stent and delivery system definition and (ii) a design strategy to efficiently optimize this system for deployment in geometries of challenging disease. Candidates should have experience in one or more of the following: computational engineering; design search and optimisation; finite element analysis (FEA); computational fluid dynamics (CFD).

If you wish to discuss any details of the project informally, please contact Dr Neil Bressloff, Computational Engineering and Design research group, Email: , Tel: +44 (0) 2380 59 5473.



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