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The University of Southampton
Engineering

Research project: Nanoparticles characterization for nanotoxity

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The establishment of relevant nanoparticle characterization parameters and testing strategies which facilitate the replication of in vivo action are essential to reaching consensus in nanotoxicity research results.

The importance of nanoparticle characterization for nanotoxicology has been extensively emphasized and it has been universally agreed that the most important parameters for characterizing nanomaterials are specific surface area and surface properties (chemistry, hydro-philicity/phobicity, charge etc). This study is proposing the use of enthalpy of wetting which depends on both specific surface area and surface properties, is easily measurable and proves to be highly relevant for predicting nanoparticles’ dispersion state and their interaction with the lungs. It also shows the conditioning effect of the lung surfactant main component, DPPC on the surface of particles when used in concentrations which mimic pulmonary exposure more closely. It also investigates the conditioning effect of the lung surfactant main component, DPPC on the surface of particles when used in concentrations which mimic pulmonary exposure more closely.

Associated research themes

Materials and surface engineering

Related research groups

national Centre for Advanced Tribology at Southampton (nCATS)

Key Publication

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