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Postgraduate research project

CASE Studentship with Haleon: High resolution 3D imaging for dentine microtubule mapping and the efficacy testing of sensitivity toothpaste formulations

Funding
Fully funded (UK only)
Type of degree
Doctor of Philosophy
Entry requirements
2:1 honours degree View full entry requirements
Faculty graduate school
Faculty of Engineering and Physical Sciences
Closing date

About the project

Dental hypersensitivity affects 33% of the adult population. It is characterised as a sharp dental pain resulting from chemical, thermal, tactile, or osmotic stimuli applied to the teeth. This project, in collaboration with Haleon, will focus on the prevention and treatment of dental hypersensitivity. 

You will use the latest serial block-face scanning electron microscopy to generate 3D visualisations of the structure of dentine. This will enhance our understanding of the structure-function relationship in the tissue and its influence on the painful stimuli suffered by dental hypersensitivity sufferers. 

A novel sensitivity paste formulation, combining 2 active ingredients, will also be developed and its efficacy tested. You will investigate the combined ingredients to understand their interaction and reaction products. The aim is to generate a positive synergistic effect to provide rapid relief to patients with hypersensitivity and enhance long-term protection and prevention.

You will have the opportunity to learn a range of experimental techniques and analysis methods, including:

  • serial block-face scanning electron microscopy
  • nanoindentation
  • x-ray diffraction 
  • nuclear magnetic resonance spectroscopy

You will also have the opportunity to spend time with the oral health research and development team at Haleon. This will provide a unique insight into paste development, formulation, production, and the steps and processes involved in taking a product to market.

External supervisors

Alongside Doctors Cook and Rankin in Southampton, your supervisors at Haleon will include:

  • Dr. Patricia Goggin
  • Dr. Behrad Mahmoodi 
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