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The University of Southampton
Biological SciencesPostgraduate study

Miss Amber Skye Cooper BSc and MRes

Postgraduate Research Student in Biological Sciences

Miss Amber Skye Cooper's photo

Amber Skye Cooper is a Postgraduate Research Student in Biological Sciences at the University of Southampton.

In 2021, Amber gained a Master of Research in Advanced Biological Sciences from the University of Southampton. During this time, she worked on a research project with Amrit Mudher studying the relationship between Type-2 Diabetes Mellitus and Alzheimer’s disease, by characterising how Tau phosphorylation profiles are influenced by insulin-mediated changes.

This year she extends her interest in Alzheimer’s disease and Tau pathology working with Prof Mudher. Utilising human Tau-expressing Drosophila melanogaster her doctoral research aims to dissect the mechanisms underpinning Tau propagation.

Academic qualifications

2020-2021: MRes in Advanced Biological Sciences. University of Southampton, UK.

2017-2020: BSc in Biomedical Sciences. University of Southampton, UK.

Research interests

I have a strong interest in Tauopathies which encompasses a large spectrum of neurodegenerative disorders including Alzheimer’s disease.

A common entity shared within these diseases is pathological (phosphorylated and aggregated) Tau inclusions, which have shown to increase in size and incidence over time during disease progression. The location and aggregation status of the Tau inclusions are used to distinguish clinical severity of Alzheimer’s disease.

Using the newly characterised olfactory system in Drosophila, and split-luciferase complementary assays my PhD will investigate the potential mechanisms of how Tau spreads pathogenically through connected regions of the brain.  

It is imperative to understand the molecular mechanisms of Tau propagation to develop potential therapeutics for this currently incurable disease.

Supervisors

Prof Amrit Mudher

Dr Douglas Allan

Dr Herman Wijnen

Dr Katrin Deinhardt

Research title

Dissecting The Mechanisms That Underpin Tau Pathology Propagation

Research funding agency/body

University of Southampton, University of British Colombia & The Gerald Kurkut Charitable Trust.

Research project

Dissecting The Mechanisms That Underpin Tau Pathology Propagation.

Research group

Neuroscience

Miss Amber Skye Cooper
School of Biological Sciences
Faculty of Environmental and Life Sciences
Life Sciences Building 85
University of Southampton
Highfield Campus
Southampton
SO17 1BJ

Room Number : 85/3041 seat 79

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