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Biological SciencesPostgraduate study

Miss Dianne Marquez Lopez BSc, Master of Research

Postgraduate research student

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Miss Dianne Lopez is a Postgraduate research student within the Biological Sciences (Neuroscience) at the University of Southampton


2013-2016: BSc Biomedical Sciences (First Class (Hons). Newcastle University, UK

2016-2017: Masters of Research in Neuroscience (Distinction). Newcastle University, UK

2018-present: PhD in Biological Sciences. Southampton University, UK

Previous research project titles:

2015 - Investigating blood biomarkers for the deferential diagnosis of dementias

2016- Investigating the neurovascular protective effects of environmental enrichment on white matter injury and microglial activation in a mouse model of chronic cerebral hyperfusion.

2017- Pharmacological Modulation of Fast Network Oscillations in the Rodent Anterior Cingulate Cortex and its Relevance to Schizophrenia

Research interests

Many neurodegenerative disorders are characterised by extensive neuronal loss and the formation of pathological protein inclusions. I am particularly interested in tau, a microtubule-associated protein, that has been shown to intracellularly aggregate into neurofibrillary tangles in the neocortex of patients diagnosed with tauopathies. The deposition and propagation of tau pathology, which correlates to clinical severity of the disease, has been attributed to the pathological release of toxic tau species in intact cells, however, the exact mechanism of transmission is still unknown.

To address this, I’m currently working on developing novel microfluidic and bioluminescent assays to elucidate the exact molecular and cellular mechanism of tau propagation in neurodegenerative diseases across minimalistic neuronal networks.

PhD in Biological Sciences

Project title: How does tau pathology propagate across neuronal networks in neurodegenerative diseases?

PhD supervision: Dr Katrin Deinhardt; Dr Mark Coldwell; Dr Jonathan West

Research group

Molecular and Cellular Biosciences

Affiliate research groups

Gerald Kerkut Trust, IfLS, Neuroscience

Research project(s)

Investigating tau propagation across neuronal networks

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Miss Dianne Marquez Lopez
School of Biological Sciences
Faculty of Environmental and Life Sciences
Life Sciences Building 85
University of Southampton
Highfield Campus
SO17 1BJ

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