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Biological SciencesPostgraduate study

 Maddy Newby BSc

Postgraduate Research Student in Viral Glycobiology

  Maddy Newby's photo

Maddy is a Postgraduate Researcher of Viral Glycobiology within the School of Biological Sciences at the University of Southampton.

2017-2020: BSc Pharmacology, University of Southampton

Research interests

The spike proteins of many enveloped viruses are key targets for vaccine design due to their susceptibility to neutralising antibodies during natural infection. Enveloped viruses undergo post-translational modification by the host’s N-linked glycosylation pathway in an act to evade the immune system. By decorating viral spike proteins with host-derived N-linked glycans, a shielding effect may arise to hide the underlying antigenic protein surface from neutralising antibodies.  As glycan processing is heterogeneous, specific workflows are required to fully characterize the glycosylation of viral envelopes, which form a portion of the antigenic surface of the virus. Using a combination of biophysical techniques, with a focus on mass spectrometry, I aim to determine the glycosylation of viral glycoproteins at the site-specific level for a number of viruses, including HIV-1, SARS-CoV-2, Ebola and Hepatitis C virus. Discovering shared mechanisms by which viral spike proteins are glycosylated will inform the vaccine design process and additionally help to understand the role of viral spike glycosylation in disease pathogenesis.

PhD Supervision

Professor Max Crispin, Professor Bill Keevil

Memberships

Member of the British Pharmacological Society

Research group

Molecular and Cellular Biosciences

Affiliate research group

Institute for Life Sciences (IfLS)

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Maddy Newby
School of Biological Sciences
Faculty of Environmental and Life Sciences
Life Sciences Building 85
University of Southampton
Highfield Campus
Southampton
SO17 1BJ
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