Skip to main navigationSkip to main content
The University of Southampton
Chemistry
Phone:
(023) 8059 6766
Email:
L.J.Brown@soton.ac.uk

Dr Lynda J Brown BSc PhD

Associate Professor of Organic Chemistry Chair of Equality, Diversity and Inclusion

Dr Lynda J Brown's photo
Related links
ResearcherID
ORCID

Dr Lynda Brown is an Associate Professor of Organic Chemistry at the University of Southampton her research focuses on the design and synthesis of molecules for imaging and medicinal chemistry applications.

Progress in chemistry research is achieved by diverse teams working together in an inclusive culture

As an organic chemist, my research involves the discovery of novel chemical entities for imaging applications. Designing efficient synthetic routes to labelled molecules incorporating fluorophores or stable isotopes (13C, 2H, 15N, 17O) enables the development of new imaging methods for widespread applications in industry and academia.

Lynda graduated with BSc degree in Applied Chemistry from the University of Aston in 1996, spending a research placement year with GlaxoSmithKline. She then moved to the University of Southampton for doctoral research on novel fluorescent oligonucleotide probes under the supervision of Prof. Tom Brown. After obtaining her PhD in 2000, she worked as a research scientist for the Life Sciences company Eurogentec. In 2003 she returned to the University of Southampton as a postdoctoral research fellow developing new strategies for the production of imaging agents for use in positron emission tomography, and then working on the total synthesis of cis-sylvaticin. In 2009, she secured a Royal Society Dorothy Hodgkin Research Fellowship to pursue projects centred on enhancing the selectivity of organic reactions by synthesis within nanopores, developing new catalytic materials. In 2015 she moved to the post of a Senior Research Fellow and in 2020 she was promoted to her current position of Associate Professor. Lynda’s research focuses on the design and synthesis of molecules for imaging and medicinal chemistry applications often incorporating multiple isotopic labels.

Lynda has a passionate commitment to equality, diversity and inclusion and chairs the ED&I team within Chemistry. She has led on Chemistry’s two Athena SWAN Silver Awards and works with the Faculty and University team to build collegiality and bring about cultural change.

Research interests

Research in my group focuses on the design and synthesis of isotopically labelled molecules to enable development of new methods in medical imaging. The molecules can be used to create hyper-polarised contrast agents that deliver enormously enhanced NMR signals (potentially many orders of magnitude over currently available technologies) with extended lifetimes allowing brighter images, and higher resolution. Designing practical and efficient routes to these isotopically labelled molecules is challenging from a synthetic perspective due to constraints of limited availability of labelled starting materials and the need for specific positioning of isotopes. Our ambition is to develop the next generation of contrast agents that incorporate water solubility and biocompatibility whilst retaining the extended lifetimes and enhanced signals. This research program is in collaboration with UoS partners Prof’s M. Levitt, R. Brown and Dr G. Pileio. In 2015, we achieved a significant research goal by synthesising an isotopically labelled naphthalene derivative that supported a nuclear singlet lifetime of more than hour, representing a remarkable advancement in the field.

Other current research interests include the synthesis of site-specifically 13C labelled retinals as probes for biological structural studies through high-resolution solid-state NMR spectroscopy (collaboration with Prof. C. Glaubitz, Institute for Biophysical Chemistry, Goethe University, Frankfurt). We also have interest in solid-phase synthesis of PET tracers and synthesis of small molecules for medicinal chemistry applications for example investigating novel methodology for the preparation of β-lactones and β-lactams.

Previous research projects have spanned the areas of natural product synthesis, solid phase chemistries, heterogeneous catalytic materials and fluorescent DNA analysis.

I have collaborated in and led research projects spanning the areas of natural product synthesis, solid phase chemistries, heterogeneous catalytic materials and fluorescent DNA analysis. My current research involves the design and synthesis of isotopically labelled molecules to enable development of new methods in medical imaging. These molecules can be used to create hyper-polarised contrast agents that deliver enormously enhanced NMR signals (potentially many orders of magnitude over currently available technologies) with extended lifetimes allowing brighter images, higher resolution and access to remote organs not currently possible. Designing practical and efficient routes to these isotopically labelled molecules is challenging from a synthetic perspective due to constraints of limited availability of labelled starting materials and specific positioning of isotopes. Our ambition is to develop the next generation of contrast agents that incorporate water solubility and biocompatibility whilst retaining the extended lifetimes and enhanced signals.

Research theme: Organic Synthesis

Developing new heterogeneous catalytic materials
Developing isotopically labelled materials for medical imaging
Synthesis of novel oxidation catalysts

Research group

Organic Chemistry: Synthesis, Catalysis and Flow

Chair of Chemistry’s Equality, Diversity and Inclusion team

Staff Engagement Survey Champion

Chemistry Advisory Board Member

Royal Society Newton International Fellowship Panel

 

 

 

Sort via:TypeorYear

Key Publications

Articles

Book Chapters

Fellow of HEA

Lecturer in Medicinal Chemistry CHEM3002/CHEM6092

Lecturer in Organic Chemistry

CHEM1049/CHEM1054

CHEM2001/CHEM2018

Undergraduate Projects and Placements

CHEM3012/CHEM6139/CHEM6102

Personal Tutor

Dr Lynda J Brown
Chemistry, University of Southampton, Highfield, Southampton SO17 1BJ

Room Number: 30/5035

Share this profile Share this on Facebook Share this on Twitter Share this on Weibo
Privacy Settings