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The University of Southampton
Chemistry
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(023) 8059 4176
Email:
S.Khalid@soton.ac.uk

Professor Syma Khalid MChem PhD

Professor of Computational Biophysics, Head of Physical Chemistry Teaching

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Professor Syma Khalid is Professor of Computational Biophysics within Chemistry at the University of Southampton.

" Our research interests are focussed on multiscale modelling and simulations of bacterial membrane and cell wall components." We are working towards developing the ‘virtual bacterial cell envelope’

 

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Syma graduated with a first class degree in Chemistry from the University of Warwick in 2000. She remained at Warwick to read for a PhD under the supervision of Professor P Mark Rodger. After obtaining her PhD in 2003, she moved to the University of Oxford as a postdoc in Professor Mark Sansom's lab, to study the structure-function relationship of bacterial membrane proteins. In 2007, she was appointed as RCUK fellow in Chemistry at the University of Southampton, in 2010 was appointed to full lectureship. In 2016 she was promoted to full professor She has ~15 years of experience in the development and application of molecular dynamics simulations to the study of biological molecules. Her research interests are centred around the dynamics of biomolecules in and around biological membranes. Her formal training as a chemist combined with her interest in the biological relevance of the systems she studies enables her to adopt a truly multi-disciplinary approach; collaborators include Bert van den Berg (Newcastle), Ben Luisi (Cambridge) Colin Kleanthous (Oxford). Syma's international reputation is reflected in the invitations she receives to speak at national and international meetings each year.

Syma has authored over 50 peer-reviewed papers and  book chapters and is on the editorial board of Scientific Reports. From November 2018 she will take over as chair of HECBiosim. She serves on the management group that leads CCPBiosim and on the management committee of the British Biophysical Society.

 

Research interests

Her research interests are centred around the dynamics of biomolecules in and around biological membranes. For example she is using atomistic and coarse-grain modelling and simulations to study the two membrane and the cell wall of E. coli. Her formal training as a chemist combined with her interest in the biological relevance of the systems she studies enables her to adopt a truly multi-disciplinary approach; collaborators include Bert van den Berg (Newcastle), Ben Luisi (Cambridge) Colin Kleanthous (Oxford). Syma's international reputation is reflected in the invitations she receives to speak at national and international meetings each year.

Syma has authored over 50 peer-reviewed papers and  book chapters and is on the editorial board of Scientific Reports.

 

PhD students:

Damien Jefferies - The interaction of natural and synthetic materials with bacterial membranes.

Graham Saunders - Modifications to lipopolysaccharide in the outer membrane of E. coli.

Taylor Haynes - Design and optimisation of nanopores for DNA sequencing.

Alister Boags - Modelling and simulation of the bacterial cell wall.

Eilish McBurnie - Interactions of antibiotics with the cell membrane of S aureus.

Jonathan Shearer - TMCS CDT

Kamolrat Somboon - Uncovering the principles of solute permeation through outer membrane proteins.

Punam Rattu - Rational design of novel nanopores for DNA sequencing.

Iain Smith - Large scale simulations of the E. coli cell envelope.

 

Computational Bacteriology

My research involves the application of computational techniques to the study of large biological molecules and systems including bacterial outer membrane proteins and nucleic acids. A key area of research involves capturing the biological complexity of bacterial membranes in our simulations, with a particular focus on the outer membranes of Gram-negative bacteria. In this context are developing computational models and tools to link biomolecular simulations and systems biology. We are also interested in applying the knowledge gained from studying biological systems to aid the design of synthetic systems for applications in bionanotechnology.

We have strong links with experimental groups in biophysics, biochemistry, chemical biology and structural biology.

Research funding

As PI

  • BBSRC Responsive mode grant: BB/M029573/1 (£322k)
  • BBSRC Industrial CASE award with Oxford Nanopore Technologies (£40k)
  • BBSRC Responsive mode grant: BBH0006581 (£295k)
  • University of Southampton Start-up funds (2 PhD studentships and £50k)
  • University of Southampton, Institute of Life Sciences: 3-month PDRA
  • University of Southampton, Institute of Life Sciences: PhD studentship
  • Industrially funded studentship (Oxford Nanopore technologies: £80k)
  • Industrially funded PDRA (Oxford Nanopore Technologies: £100k)
  • University of Southampton, Institute of Life Sciences: (£20k)
  • University of Southampton, strategic funding (£22k)

As Co-I

  • EU-funded Marie Curie ITN grant as Co-PI (€3.82M) PI is Alison Rodger (Warwick)
  • MRC-funded Project on AMR (theme 1) as Co-PI (£5m) PI is Christopher Dowson (Warwick)

 

 

Research group

Computational Systems Chemistry

Affiliate research group

Institute for Complex Systems Simulation

Research project(s)

Khalid: Self Assembly of DNA-lipid complexes for gene therapy

Khalid: Transport mechanisms in bacteria: Autotransporters

Head of physical chemistry teaching.

From November 2018 she will take over as chair of HECBiosim.

On the management group of CCPBiosim.

On the management committee of the British Biophysical Society.

Consultant to Oxford Nanopore Technologies Ltd.

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Professor Syma Khalid
Chemistry University of Southampton Highfield Southampton SO17 1BJ

Room Number: 27/2007


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