Most biological processes involve interactions between macromolecules. The module discusses selected examples and explains techniques used to study molecular interactions.
BIOL2010 AND BIOL2012
Having successfully completed this module you will be able to:
The module discusses ways in which signal transduction events lead to altered gene expression. Cytokines and growth hormones and their receptors are discussed, affecting cell cycle regulation. Protein-peptide recognition will be introduced, and will see how viruses upset cell regulation through interfering peptides. The receptors themselves are often multi-domain proteins. Assembly of multiple domains is a requirement for regulation and efficient binding site presentation. The structure of DNA and the recognition of nucleic acids by interacting proteins such as histones, nucleases, and transcription factors is introduced. Also discussed are the structures of RNA and riboswitches. Methods to study macromolecular interactions are introduced in all sections. The seminal technique of mass spectrometry is covered in detail to explain protein-ligand interactions. Hydrogen–deuterium exchange (HDX) mass spectrometry allows to studying protein-protein interactions.
Lectures and independent study.
| Type | Hours |
|---|---|
| Lecture | 24 |
| Independent Study | 126 |
| Total study time | 150 |
This is how we’ll formally assess what you have learned in this module.
| Method | Percentage contribution |
|---|---|
| Written assessment | 100% |
This is how we’ll assess you if you don’t meet the criteria to pass this module.
| Method | Percentage contribution |
|---|---|
| Written assessment | 100% |