Medicinal Chemistry is pivotal in the design, synthesis and evaluation of new medicines, and involves multidisciplinary research at the interface of Chemistry, Biology and Medicine. This module will introduce key molecular concepts and methods in Medicinal Chemistry, and the central role played by chemists in the development of drug candidates targeting diverse disease states and their associated biomolecular targets (for example proteins, DNA). Through important historical case studies, we will discuss the properties and modes of action of pharmaceuticals in biological systems, from “classical” inhibitors to more contemporary and cutting-edge bioactive compounds, such as protein degraders, pharmacological chaperones, and targeted covalent inhibitors. Students will have access to a broad range of resources, including recent specialist literature and software, along with additional recorded content that illustrate important concepts covered in the lectures.
Pre-requisite(s): CHEM2028 and CHEM2031