Aims and Objectives
Having successfully completed this module you will be able to:
- Describe how metals can be utilised in medical applications from both a therapeutic and diagnostic perspective.
- Be able to provide a sound basis for the macrocyclic effect in terms of both kinetic and thermodynamic considerations, and link this closely to the potential and actual applications of macrocyclic systems in a range of domains, including a detailed understanding of the key factors influencing the design of macrocyclic frameworks suitable for the selective extraction of particular metal ions (s-block, p-block and 1st row d-block).
- Demonstrate detailed appreciation of the challenges and solutions associated with the successful preparation of macrocycles with a range of donor atom types (O, N, S, Se, P) and their complexes, as well as developing the necessary skills in analysing and interpreting spectroscopic and analytical data on these systems, so that previously unseen examples and/or reaction schemes may be correctly identified and rationalised.
- Demonstrate an appreciation of how and why macrocyclic ligands can support coordination of metal ions in unusual oxidation states, how to optimise these characteristics for particular metals and their development towards electrocatalysis.
- Describe in detail how metal ions are important in biological processes and why the coordination environment around the metal centre plays a crucial role in its function.
The special properties of macrocyclic ligands are described together with issues surrounding their syntheses. The applications of macrocycles and their complexes in selective metal ion extraction, catalysis and in biological systems are highlighted, together with their particular ability to stabilise uncommon metal oxidation states.
The role that metal ions play in biological systems will be discussed. With an emphasis on ion transport and storage, biological metal redox processes, the role metals play in enzymes and how metal compounds are utilised in medicine.
Learning and Teaching
Teaching and learning methods
Teaching: Lectures, workshops
Learning: consolidation of lecture notes, with reading around the topics to develop further detail; tackling problem questions in workshops, etc.
|Practical classes and workshops||2|
|Preparation for scheduled sessions||40|
|Practical classes and workshops||4|
|Total study time||150|
Resources & Reading list
L.F. Lindoy, G.V. Meehan, I.M. Vasilescu, H.J. Kim, J.-E. Lee, S.S. Lee (2010). Transition and post-transition metal ion chemistry of dibenzo-substituted, mixed-donor macrocycles incorporating five donor atoms. Coord Chem. Rev., 254, pp. 1713.
J. A. McCleverty and T. J. Meyer (2004). Thioether, Selenoether and Telluroether Macrocycles. Comprehensive Coordination Chemistry II, 1, pp. 399.
S. Faulkner and N. Long (2011). Radiopharmaceuticals for Imaging and Therapy. Dalton Trans., 40, pp. 6067.
J. A. McCleverty and T. J. Meyer (2004). Phosphine and Arsine Macrocycles. Comprehensive Coordination Chemistry II, 1, pp. 475.
T. Johnstone, K. Suntharalingam, and S. J. Lippard (2016). The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs. Chem. Rev., 116 (5), pp. 3436.
P.C. Wilkins and R.G. Wilkins (1997). Inorganic Chemistry in Biology. Oxford Chemistry Primer 46, OUP.
L.F. Lindoy (1989). The Chemistry of Macrocyclic Ligand Complexes. Cambridge: Cambridge University Press.
D. E. Fenton (1995). Biocoordination Chemistry. Oxford University Press.
J. C. Dabrowiak (2009). Metals in Medicine. John Wiley & Sons, Ltd..
E.C. Constable (1999). The Coordination Chemistry of Macrocyclic Compounds. Oxford Chemistry Primer No 72, OUP.
R. K. Zalups, D. J. Koropatnick (2010). Cellular and Molecular Biology of Metals. CRC Press.
This is how we’ll formally assess what you have learned in this module.
This is how we’ll assess you if you don’t meet the criteria to pass this module.
|Coursework marks carried forward||10%|
Repeat type: Internal & External