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The University of Southampton

CHEM6162 Advanced Chemical Biology

Module Overview

Aims and Objectives

Learning Outcomes

Learning Outcomes

Having successfully completed this module you will be able to:

  • Describe essential techniques employed in chemical biology for the synthesis, characterisation and engineering of biomolecules.
  • Draw the structure of common biorthogonal reagents and the molecular mechanisms (curly arrows) underlying protein labelling.
  • Discuss the mode of action of important classes of chemical probes.
  • Highlight key applications of synthetic methods to understanding the biological function of carbohydrate based biomolecules.
  • Understand the importance of chemical biology methods for the discovery of novel drugs to treat diseases.


• Proteins, nucleic acids and their characterisation • Protein engineering, directed evolution and synthetic biologicals • Chemical probes to study biomolecules: design and mode of action • Bioconjugation reactions and labelling of peptides and proteins • Understanding glycobiology with chemistry

Learning and Teaching

Teaching and learning methods

Lectures, workshops

Preparation for scheduled sessions6
Wider reading or practice44
Total study time124



MethodPercentage contribution
Final Assessment   (120 minutes) 100%

Repeat Information

Repeat type: Internal & External

Linked modules


To study this module, you will need to have studied the following module(s):

CHEM3038Advanced Organic Chemistry (Bioorganic)
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