The Natural Sciences degree programme is based on a backbone of modules that employ context-based (also referred to as problem-based or active learning). This approach to learning places significant responsibility on the students to identify sources of information, to retrieve technical information, to assess information critically and to apply relevant information to a specific task or problem. This module provides students with in introduction to drug design from medical, chemical and structural biology perspectives.
Aims and Objectives
Having successfully completed this module you will be able to:
- a critical understanding of protein-inhibitor binding kinetics and thermodynamics
- a good understanding of how to design an inhibitor matched to a given active site structure
- the ability to access and interrogate protein structure databases
- strategies for acquiring, collating and presenting information from literature, written and oral
- ability to defend own work
- the ability to determine the effectiveness of a new inhibitor
- skills in determining protein-inhibitor binding kinetics
- ability to analyse, interpret and present complex information from cutting-edge research publications
The module will be delivered in the context of designing, synthesising and evaluating a small-molecule inhibitor of a target protein. Three main areas will be addressed: structural biology & databases, pharmacokinetics and inhibitor design, as well as medicinal applications. Topics include retrieval and analysis of 3D structure models, comparison of atomic models, and visualisation using the software PyMOL. Enzyme kinetics, enzyme inhibitors as well as ligand-receptor binding kinetics, IC50 and dose responses are discussed. Animal models and testing of novel drugs are discussed, as are medicinal applications.
Learning and Teaching
Teaching and learning methods
The philosophy underlying this course is to empower students to take charge of their own learning in the area of rational drug design. As a consequence, this module will make extensive use of directed and peer-assisted self-learning methods. Includes learning and application of a graphics display software for atomic structure models of biomolecules, as well as presentation of data in different formats (assay, oral presentation, poster presentation.
|Practical classes and workshops||20|
|Total study time||150|
This is how we’ll formally assess what you have learned in this module.
|Poster presentation and defence||40%|
|Individual Oral Presentation||30%|
Repeat type: Internal & External