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Research project

CCP4: Advanced integrated approaches to macromolecular structure determination

Staff

Lead researcher

Dr Ivo Tews

Associate Professor

Research interests

  • Natural products biosynthesis: a complex cascade of catalytic steps in vitamin B6 biosynthesis is characterised by structures or reaction intermediates in the large PLP syntase complexEdit
  • Bacterial biofilms: understanding of RedOx regulated phosphodiesterase activity in dispersal of biofilms to address chronic infections
  • Cancer immunology: together with Cancer Immunology at Southampton we use a structure based apporach in developing novel cancer therapie

Collaborating research institutes, centres and groups

National Biofilms Innovation Centre (NBIC)

NBIC is the central hub where academia, industry, government and public policy come together to tackle the grand challenges biofilms present, impacting $4 trillion in global economic activity.

Molecular and Precision Biosciences

We research how molecular machinery governs cellular life, developing tools to tackle diseases caused when these molecular operations are disrupted.

Research outputs

Successful sample preparation for serial crystallography experiments
John H. Beale,
Rachel Bolton,
Stephen A. Marshall,
Emma V. Beale,
Stephen B. Carr,
Ali Ebrahim,
Tadeo Moreno-Chicano,
Michael A. Hough,
Jonathan A.R. Worrall,
Ivo Tews,
& Robin L. Owen
, 2019 , Journal of Applied Crystallography , 52 (Pt 6) , 1385--1396
DOI: 10.1107/S1600576719013517
Type: article
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