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Research project

Investigating lipophilicity and hydrogen bonding properties of functionalised aliphatic compounds

Staff

Other researchers

Professor Phil Williamson

Head of School
Research interests
  • Molecular processes underpinning neurodegenerative disease
  • Structure and function of cell membranes
  • Development and application of solid-state NMR and other biophysical techniques for the analy…
Connect with Phil

Email: P.T.Williamson@soton.ac.uk

Collaborating research institutes, centres and groups

Research outputs

Relating Conformational Equilibria to Conformer-Specific Lipophilicities: New Opportunities in Drug Discovery
2022, Angewandte Chemie, 61(7)
DOI: 10.1002/anie.202114862
Type: article
Lipophilicity trends upon fluorination of isopropyl, cyclopropyl and 3-oxetanyl groups
2020, Beilstein Journal of Organic Chemistry, 16(16), 2141-2150
DOI: 10.3762/bjoc.16.182
Type: article
Fluorinated carbohydrates as chemical probes for molecular recognition studies. Current status and perspectives
2020, Chemical Society Reviews, 49(12), 3863-3888
DOI: 10.1039/C9CS00099B
Type: review
A systematic investigation of lipophilicity modulation by aliphatic fluorination motifs
2020, Journal of Medicinal Chemistry, 63(3), 1002-1031
DOI: 10.1021/acs.jmedchem.9b01172
Type: article
A new straightforward method for lipophilicity (logP) measurement using 19F NMR spectroscopy
Zhong Wang, Benjamin Jefferies, Hannah, Rebecca Felstead, Neil J. Wells, Elisabetta Chiarparin & Bruno Linclau, 2019
DOI: 10.3791/58567
Type: creativeMediaAndArtefact
Reducing the lipophilicity of perfluoroalkyl groups by CF2–F/CF2-Me or CF3/CH3 exchange’
2018, Journal of Medicinal Chemistry, 61(23), 10602-10618
DOI: 10.1021/acs.jmedchem.8b01222
Type: article