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Research project

Investigating lipophilicity and hydrogen bonding properties of functionalised aliphatic compounds

Staff

Other researchers

Professor Phil Williamson

Head of School

Research interests

  • Molecular processes underpinning neurodegenerative disease
  • Structure and function of cell membranes
  • Development and application of solid-state NMR and other biophysical techniques for the analysis of biological systems

Collaborating research institutes, centres and groups

Organic Chemistry, Synthesis, Catalysis

We develop environmentally sustainable approaches to chemical manufacture that minimise chemical waste, improve product velocity and reduce the need to isolate intermediates.

Research outputs

Relating Conformational Equilibria to Conformer-Specific Lipophilicities: New Opportunities in Drug Discovery
Bruno Linclau,
Zhong Wang,
Benjamin Jefferies,
Jerome Graton,
Jean-Yves Le Questel,
Jesus Carbajo San Martin,
James S. Scott,
& Davy Sinnaeve
, 2022 , Angewandte Chemie , 61 (7)
DOI: 10.1002/anie.202114862
Type: article
A systematic investigation of lipophilicity modulation by aliphatic fluorination motifs
Benjamin Francis Joseph Jeffries,
Zhong Wang,
Hannah, Rebecca Felstead,
Jean-Yves Le Questel,
James Scott,
Elisabetta Chiarparin,
Jérôme Graton,
& Bruno Linclau
, 2020 , Journal of Medicinal Chemistry , 63 (3) , 1002--1031
DOI: 10.1021/acs.jmedchem.9b01172
Type: article
Fluorinated carbohydrates as chemical probes for molecular recognition studies. Current status and perspectives
Bruno Linclau,
Niels C. Reichardt ,
Matthieu Sollogoub,
Luca Unione,
Stéphane P. Vincent ,
& Jesús Jiménez-Barbero
, 2020 , Chemical Society Reviews , 49 (12) , 3863--3888
DOI: 10.1039/C9CS00099B
Type: review
Lipophilicity trends upon fluorination of isopropyl, cyclopropyl and 3-oxetanyl groups
Benjamin Jefferies,
Zhong Wang,
Robert Ian Troup,
Anaïs Goupille,
Jean-Yves Le Questel,
Charlene Fallan,
James S. Scott,
Elisabetta Chiarparin,
Jérôme Graton,
& Bruno Linclau
, 2020 , Beilstein Journal of Organic Chemistry , 16 (16) , 2141--2150
DOI: 10.3762/bjoc.16.182
Type: article
A new straightforward method for lipophilicity (logP) measurement using 19F NMR spectroscopy
Zhong Wang,
Benjamin Jefferies,
Hannah, Rebecca Felstead,
Neil J. Wells,
Elisabetta Chiarparin,
& Bruno Linclau
, 2019
DOI: 10.3791/58567
Type: creativeMediaAndArtefact
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