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Research project

Prof A Postle 093500/Z/10/Z Mass Spectrometer

Staff

Other researchers

Professor John Langley

Professorial Fellow-Enterprise

Research interests

  • The application of separation science and mass spectrometry as a routine tool for chemistry/chemical biology/oilfield chemistry;
  • Probing new areas for research using these tools;
  • The application of hyphenated approaches (GC-MS, GCxGC-MS, HPLC-MS & SFC-MS).
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Emeritus Professor Geraldine Clough

Research interests

  • Early identification of risk of small vessel dysfunction in cardio-metabolic disease
  • Mechanisms underlying the developmental priming of vascular plasticity and endothelial dysfunction by maternal diet
  • Development of novel devices and approaches for the multiscale assessment of the dynamics of microvascular perfusion
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Dr Ashley Pringle

Principal Teaching Fellow
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Professor Ratko Djukanovic

Professor of Medicine

Research interests

  • Professor Djukanovic has a lifelong interest in asthma, especially its severe forms. where his focus is on: 1) underlying pathobiological mechanisms of asthma, 2) stratification of asthma into clinical phenotypes and mechanism-based endotypes, 3) unmet needs of severe asthma management. He also has an interest in the mechanisms and treatments of severe viral infections of the lung.
  • Underlying mechanisms of asthma: Professor Djukanovic has conducted pioneer studies into the pathology of asthma, applying research bronchoscopy  (with endobronchial biopsy and bronchoalveolar lavage) and sputum induction. He led the initial task forces which defined the use of these two techniques, thereby paving the way for standardised research approches that enabled in-depth descriptions of the roles of various inflammatory cells and their mediators. He developed an explant model, consisting of bronchial biopsies placed into tissue culture, that could be stimulated ex vivo with relevant triggers, applying as needed, novel agents not yet approved for in vivo use in humans volunteers. 
  • Stratification of asthma into clinical phenotypes and mechanism-based endotypes: Professor Djukanovic led the discovery of biomarkers using omics technology (transcriptomics, proteomics, lipidomics, breathomics). After the first ever study of transcriptomics biomarkers in the epithelium of patients with Chronic Obstructive Pulmonary Disease (COPD), together with a colleague from Amsterdam and two colleagues from Imperial College, London, he created a large (€27 milllion) programme for severe asthma (U-BIOPRED), funded by the EU Innovative Medicines Initiative. This has resulted in more than 100 publications, providing insight into novel phenotypes and endotypes of asthma.
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Research outputs