Research project

Rapid Detection of Human Pathogens in Ocular Surface Infectious Disease

Project overview

Ocular surface infectious diseases are the leading cause of unilateral visual loss worldwide. The World Health Organisation estimates that 20 million are losing their eyesight annually. Ocular infections constitute a significant component of this vision loss. Delays in diagnosis, inappropriate antimicrobial use and anti-microbial resistance are all factors for poor visual outcomes. Additionally, the lack of understanding of the immune response during infection results in poor decision-making regarding anti-inflammatory therapy interventions1,2.

In collaboration with NHS Ophthalmology, Molecular Biology (Clinical Experimental Sciences) and iFAST (University Spin-Out commercialising a new rapid Antimicrobial Susceptibility Test), we have developed a novel platform for rapidly assessing ocular surface infections. This test uses microfluidic impedance cytometry to provide a susceptibility profile of a bacterial sample in 2 hours. It has been tested at the UK Health Security Agency on 50 different strains/species against a panel of different antibiotics to develop insights into the mode of action of phage infection3. We have also found that the technology detects cellular immune responses during human ocular infection.


Lead researcher

Mr Parwez Hossain MBChB PhD FHEA FRCOphth FRCS (Ed)

Associate Professor

Research interests

  • Corneal Infection
Connect with Parwez

Research outputs