Research project

Understanding microglial development in the rodents and human brain

Research groups:

Neuroscience
Lead researchers:

Professor Diego Gomez-Nicola
Research funder:

Leverhulme Trust
Status:

Not active

Project overview

Understanding the dynamics and phenotype of microglia during development is a fundamental aspect when trying to elucidate the contribution of these cells to normal and abnormal neurodevelopment. In this project we are looking at defining the key mechanisms controlling the microglial population during critical neurodevelopment windows, using in depth phenotypic of pots-mortem human samples as well as rodent models.

Staff

Lead researchers

Professor Diego Gomez-Nicola PhD

Professor

Research interests

Neuroimmunology
Neurodegeneration
Neurodevelopment

Connect with Diego

Email: D.Gomez-Nicola@soton.ac.uk

Collaborating research institutes, centres and groups

Neuroscience

We work on national and global priorities of health and well-being, underpinning research in neuroscience, and age-related neurodegenerative diseases, including Alzheimer’s.

Research outputs

Autism spectrum disorders: multiple routes to, and multiple consequences of, abnormal synaptic function and connectivity

Liam Carroll, Sven Braeutigam, John M. Dawes, Zeljka Krsnik, Ivica Kostovic, Ester Coutinho, Jennifer Dewing, Christopher Horton, Diego Gomez-Nicola & David Menassa, 2021, The Neuroscientist, 27(1), 10-29

DOI: 10.1177/1073858420921378

Type: article

Development and maintenance of the brain's immune toolkit

Jose P. Lopez-Atalaya, Katharine E. Askew, Amanda Sierra & Diego Gomez-Nicola, 2017, Developmental Neurobiology, 78(6), 561-579

DOI: 10.1002/dneu.22545

Type: review