About the project
This PhD project aims to develop new approaches for cancer therapy, focusing on head and neck cancer. You will explore the role cancer-associated fibroblasts (CAF) have in regulating anti-tumour immunity and suppressing response to immunotherapy.
Active research themes in the lab include:
- characterising CAF phenotypes in human tumours using single cell sequencing
- studying CAF interactions with immune cells
- identifying novel strategies for therapeutic targeting of CAF-containing cancers
You will use a broad range of techniques and skills in the following:
- cell culture
- molecular biology
- cell-based functional assays
- single cell RNA sequencing and bioinformatics
- analysis of human cancers
- mouse models
We enjoy close links with University Hospital Southampton and have a strong translational focus with excellent prospects for developing new therapies and making a significant contribution to cancer treatment. You will enjoy working in a vibrant multidisciplinary environment and take advantage of our ongoing collaborations with multiple industry collaborators. There will be significant opportunities for excellent career development.
