Dr Charles Eldrid MSci, PhD

Research Fellow in mass spectrometry (glycoproteomics)

Dr Eldrid joined in 2021 the Crispin group following his PhD on understanding protein unfolding and dynamics using ion mobility-mass spectrometry.

2012-2016 Biochemistry MSci – University College London

2016-2020 PhD in studying protein unfolding using ion mobility-mass spectrometry – Konstantinos Thalassinos as University College London

Research

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Research interests

Interested in understanding creating full pictures of proteins using a variety of MS based techniques.

Research group

Molecular and Cellular Biosciences

Affiliate research group

Institute for Life Sciences (IfLS)

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Articles

Ridgway, Z., Lee, K-H., Zhyvoloup, A., Wong, A., Eldrid, C., Hannaberry, E., Thalassinos, K., Abedini, A., & Raleigh, D. P. (2020). Analysis of Baboon IAPP provides insight into amyloidogenicity and cytotoxicity of human IAPP. Biophysical Journal, 118(5). https://doi.org/10.1016/j.bpj.2019.12.027
Ridgway, Z., Eldrid, C., Zhyvoloup, A., Ben-Younis, A., Noh, D., Thalassinos, K., & Raleigh, D. P. (2020). Analysis of proline substitutions reveals the plasticity and sequence sensitivity of human IAPP amyloidogenicity and toxicity. Biochemistry, 59(6), 742-754. https://doi.org/10.1021/acs.biochem.9b01109
Eldrid, C., O'Connor, E., & Thalassinos, K. (2020). Concentration‐dependent coulombic effects in travelling wave ion mobility spectrometry collision cross section calibration. Rapid Communications in Mass Spectrometry. https://doi.org/10.1002/rcm.8613
Eldrid, C., & Thalassinos, K. (2020). Developments in tandem ion mobility mass spectrometry. Biochemical Society Transactions, 48(6), 2457–2466. https://doi.org/10.1042/BST20190788
Eldrid, C., Ujma, J., Kalfas, S., Tomczyk, N., Giles, K., Morris, M., & Thalassinos, K. (2019). Gas phase stability of protein ions in a cyclic ion mobility spectrometry traveling wave device. Analytical Chemistry, 91(12). https://doi.org/10.1021/acs.analchem.8b05641
Tosi, T., Hoshiga, F., Millership, C., Singh, R., Eldrid, C., Patin, D., Mengin-Lecreulx, D., Thalassinos, K., Freemont, P., & Gründling, A. (2019). Inhibition of the Staphylococcus aureus c-di-AMP cyclase DacA by direct interaction with the phosphoglucosamine mutase GlmM. PLoS Pathogens. https://doi.org/10.1371/journal.ppat.1007537
Kay-Hui, G., Gardener, A. D., Begum, H., Eldrid, C., Thalassinos, K., Gor, J., & Perkins, S. (2019). The solution structure of the human IgG2 subclass is distinct from those for human IgG1 and IgG4 providing an explanation for their discrete functions. Journal of Biological Chemistry, 10789-10806. https://doi.org/10.1074/jbc.ra118.007134

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Dr Charles Eldrid
School of Biological Sciences
Faculty of Environmental and Life Sciences
Life Sciences Building 85
University of Southampton
Highfield Campus
Southampton
SO17 1BJ

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