Research interests
Previous research projects, supervised within the Computational & Systems Biology group (UoS), involved combined genomics and proteomics data analysis.
Initially, identified tissue-specific enhancer regions in GWAS data for coronary artery disease SNPs and the specific genes affected.
Later research centered on a comparison of the effects of DNMT1 deficiency on gene expression, in order to determine a stronger correlation to altered protein interactions or to genome-wide differential methylation patterns.
Current PhD research aims to capitalise upon novel techniques recently developed within the labs of Dr Paul Skipp and Professor Tim Elliott to characterise quantitatively the localisation, type of covalent modifications and the peptide antigens presented by selected skin and respiratory chemical sensitisers.
Supervisor: Dr Paul Skipp
PhD Research: Distinguishing chemical sensitisation at the level of antigen formation
Funding: University of Southampton & Unilever Plc. collaborative
Research group
Computational and Systems Biology
Mr Alexander LesterSchool of Biological Sciences
Faculty of Environmental and Life Sciences
Life Sciences Building 85
University of Southampton
Highfield Campus
Southampton
SO17 1BJ
Room Number: 85/4041