Mr Alexander Lester MSci AMRSB

Postgraduate Research Student in Centre for Proteomic Research

Alex is a postgraduate researcher working within the Centre for Proteomic Research in the Faculty of Environmental and Life Sciences. He graduated with MBiochem Master of Biochemistry from the University of Southampton in 2018 through combined interest in laboratory and bioinformatics research, before returning to the university to continue his career in systems biology as a PhD student.

Academic Qualifications

2014-2018: MBiochem Master of Biochemistry. University of Southampton, UK.

Research

Publications

Contact

Research interests

Previous research projects, supervised within the Computational & Systems Biology group (UoS), involved combined genomics and proteomics data analysis.

Initially, identified tissue-specific enhancer regions in GWAS data for coronary artery disease SNPs and the specific genes affected.

Later research centered on a comparison of the effects of DNMT1 deficiency on gene expression, in order to determine a stronger correlation to altered protein interactions or to genome-wide differential methylation patterns.

Current PhD research aims to capitalise upon novel techniques recently developed within the labs of Dr Paul Skipp and Professor Tim Elliott to characterise quantitatively the localisation, type of covalent modifications and the peptide antigens presented by selected skin and respiratory chemical sensitisers.

Supervisor: Dr Paul Skipp
PhD Research: Distinguishing chemical sensitisation at the level of antigen formation
Funding: University of Southampton & Unilever Plc. collaborative

Research group

Computational and Systems Biology

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Article

Bowler, E. H., Smith-Vidal, A., Lester, A., Bell, J., Wang, Z., Bell, C., Wang, Y., Divecha, N., Skipp, P., & Ewing, R. M. (2019). Deep proteomic analysis of Dnmt1 mutant/hypomorphic colorectal cancer cells reveals dysregulation of epithelial-mesenchymal transition and subcellular re-localization of Beta-Catenin. Epigenetics, 15(1-2), 107-121. https://doi.org/10.1080/15592294.2019.1656154, https://doi.org/10.1080/15592294.2019.1656154

Letter/Editorial

McKibben, S., Bush, A., Thomas, M., & Griffiths, C. (2019). Correction to: “Tossing a coin:” defining the excessive use of short-acting beta2-agonists in asthma—the views of general practitioners and asthma experts in primary and secondary care (npj Primary Care Respiratory Medicine, (2018), 28, 1, (26), 10.1038/s41533-018-0096-4). NPJ primary care respiratory medicine, 29(1), 1. [1]. https://doi.org/10.1038/s41533-018-0114-6

Mr Alexander Lester
School of Biological Sciences
Faculty of Environmental and Life Sciences
Life Sciences Building 85
University of Southampton
Highfield Campus
Southampton
SO17 1BJ

Room Number NNN: 85/4041

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