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The University of Southampton
Biological SciencesPostgraduate study
Email:
a.sudol@soton.ac.uk

Miss Abigail Sudol MSci (Hons)

Postgraduate research student

Miss Abigail Sudol's photo

Miss Abigail Sudol is a postgraduate research student within the School of Biological Sciences, University of Southampton.

I am a postgraduate researcher within Biological Sciences, studying engineered antibodies for use in immunotherapy, primarily using biophysical techniques including x-ray crystallography.

2015-2019: MSci in Biochemistry from University of Bristol, UK

Research interests

My research focuses on the use of engineered antibodies in immunotherapy, with a focus on antibodies for breast cancer. I am currently working on some antibodies engineered to contain an additional disulphide bond in their lower hinge region, with the aim of restricting the movement of the N-linked glycans at N297 in the Fc region. I plan to study the resulting effects on glycan conformation and binding to Fc gamma receptors using x-ray crystallography and surface plasmon resonance.

Other tagrets for crystallography include the bacterial enzyme IdeS, which specifically cleaved IgG and is currently in phase 2 clinical trials for use in organ transplantation. I aim to obtain a crystal structure of this protein in complex with IgG1 Fc, in order to elucidate the molecular-level detail of its enzymatic activity.

Research project: Engineered antibodies for improved immunotherapies against breast cancer

Supervisors:

Prof Max Crispin
Dr Ivo Tews

Funding Agency: Against Breast Cancer

Research group

Molecular and Cellular Biosciences

Affiliate research group

Institute for Life Sciences (IfLS)

Miss Abigail Sudol
School of Biological Sciences
Faculty of Environmental and Life Sciences
Life Sciences Building 85
University of Southampton
Highfield Campus
Southampton
SO17 1BJ

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