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Biological SciencesPostgraduate study

Miss Lauren McNicholas MNeuroSci

Postgraduate Research Student in Biological Sciences

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Miss Lauren McNicholas is a Postgraduate Research Student within Biological Sciences at the University of Southampton.

Academic qualifications

2014-2018: First Class (Hons) Integrated Masters of Neuroscience. University of Southampton, UK.

Research interests

A successful therapy for Alzheimer’s Disease must act to modify the disease whilst leaving endogenous mechanisms intact to ensure normal neuronal function. This includes synaptic function and plasticity. Inhibition of molecular cascades downstream of amyloid beta to prevent NMDAR-mediated excitotoxicity is an area of drug target research and clinical trials. I am interested in whether these therapies can also preserve basal mechanisms of synaptic function and plasticity. To investigate this, I will be using mouse models of Alzheimer’s Disease as well as human resected brain tissue. This is an exciting area of research as it will be able to contribute to our knowledge of mechanisms for drugs in clinical trials.

PhD supervision: Dr Mariana Vargas-Caballero Dr Katrin Deinhardt
PhD Research: Ups and downs of NMDA receptor phosphorylation: relevance for synaptic function in Alzheimer’s Disease. 
PhD Funding: Alzheimer’s Research UK & The Gerald Kerkut Trust

Research group


Affiliate research group

Southampton Neuroscience Group (SoNG)

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Miss Lauren McNicholas
School of Biological Sciences
Faculty of Environmental and Life Sciences
Life Sciences Building 85
University of Southampton
Highfield Campus
SO17 1BJ

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