Research project: Understanding the role of early-life inflammation on the incidence of Alzheimer’s disease
This project aims to investigate the impact of early-life systemic inflammation on the onset and progression of Alzheimer’s disease. Microglial cells are the resident immune cells of the brain and play crucial roles in the regulation of normal and pathological neural functions. This PhD project will investigate how risk factors associated with the onset of Alzheimer’s disease modulate the physiology of microglia, helping to better understand the roles of these cells in the brain, through a multidisciplinary approach using in vivo models, genetic molecular tools and analysis of brain function.