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The University of Southampton
Chemistry

Research project: Attard: Biologically Active Amphiphiles

Currently Active: 
Yes

The aim of this research programme is to investigate the relationships between chemical structure, aggregation behaviour, and biological activity in naturally occurring and synthetic amphiphiles.

Current projects involve the design, synthesis, characterization, and evaluation of glycolipid and phopholipid analogues that have anti-neoplastic and virucidal properties. This work is part of a collaboration with colleagues at the Southampton General Hospital, and at the Welsh School of Pharmacy. A further area of research is concerned with novel amphiphiles that have immunomodulatory properties, and with synthetic virus-like aggregates for the delivery of oligopeptides. Research on these systems, which are of interest as components in synthetic vaccines, involves a collaboration with immunologists at St. Bartholomew's Hospital.

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