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The University of Southampton
Chemistry

Research project: Khalid: Designing Biosensors

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In collaboration with Professor Hagan Bayley (Oxford) and Oxford NanoLabs we are developing robust and efficient biosensors suitable for the detection of a variety of analytes.

Stochastic biosensors are built around a membrane containing a cylindrically shaped protein (usually a bacterial outer membrane protein). A voltage applied across the membrane generates an ionic current that pulls charged analyte molecules through the pore. As the analyte molecule is pulled through the nanopore, it blocks the current by a characteristic amount, thus leaving a trace of itself. The characteristic decrease in the current arising from differences in their chemical properties allows discrimination between different analyte molecules.

In collaboration with Professor Hagan Bayley (Oxford) and Oxford NanoLabs we are developing robust and efficient biosensors suitable for the detection of a variety of analytes. Currently we have focused our attention on the bacterial toxin alpha hemolysin from and outer membrane protein G. Our recent MD simulations of the outer membrane protein G (OmpG) identified ways in which the spontaneous gating of this protein could be reduced- this is essential for biosensing applications. Currently we are working towards reducing or eliminating the remaining activity that is inherent to this protein.

Related research groups

Computational Systems Chemistry
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