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The University of Southampton
Chemistry

Research project: Levitt: Molecular Structure Determination by Solid-State NMR

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Solid-state NMR is one of the most promising methods for determining the molecular structures of solid materials that do not come in the form of crystals.

Examples include glasses and many biomolecules such as proteins. For example, the proteins that cause Alzheimer's disease accumulate in the form of fibrous residues, which are inherently non-crystalline. We are developing solid-state NMR methods for determining the molecular structures of such materials, which is an essential step in understanding their properties and how they form.

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Figure: Molecular structure of zeolite, determined in our group by solid-state NMR.

 

References:

D. H. Brouwer, P. E. Kristiansen, C. A. Fyfe and M. H. Levitt, "Symmetry-Based 29Si Dipolar Recoupling Magic Angle Spinning NMR Spectroscopy: A New Method for Investigating Three-Dimensional Structures of Zeolite Frameworks", J. Am. Chem. Soc., 127, 542-543 (2005).

D. H. Brouwer, R. J. Darton, R. E. Morris and M. H. Levitt, "A solid-state NMR method for the solution of zeolite crystal structures", J. Am. Chem. Soc., 127, 10365-10370 (2005).

P. E. Kristiansen, M. Carravetta, J. D. van Beek, W. C. Lai and M. H. Levitt, "Theory and Applications of Supercycled Symmetry-Based Recoupling Sequences in Solid-State NMR". J. Chem. Phys., 124, 234510-19 (2006).

I. Marin-Montesinos, G. Mollica, M. Carravetta, A. Gansmüller, G. Pileio, M. Bechmann, A. Sebald and M. H. Levitt, "Truncated dipolar recoupling in solid-state nuclear magnetic resonance", Chem. Phys. Letters 432, 572-578 (2006).

G. Pileio, Y. Guo, T. N. Pham, J. M. Griffin, M. H. Levitt and S. P. Brown, "Residual dipolar couplings by off-magic-angle spinning in solid-state nuclear magnetic resonance spectroscopy", J. Am. Chem. Soc., 129, 10972-10973 (2007).

Related research groups

Magnetic Resonance
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