The University of Southampton
Courses

BIOL2013 Bioinformatics & DNA Technology

Module Overview

The module covers several major topics in bioinformatics and DNA technology including an introduction to bioinformatics and its role in modern 'Omics technologies; developments in DNA sequencing technologies; bioinformatic analyses of DNA; sequence alignment and biological databases; recombinant DNA techniques involving the use of different types of vector and host cells; molecular transactions involving DNA (e.g. recombination and transposition); and Epigenomics.

Aims and Objectives

Module Aims

The aims of the module are to provide an understanding of key modern molecular technologies, their exploitation and application and the bioinformatics analyses involved.

Learning Outcomes

Learning Outcomes

Having successfully completed this module you will be able to:

  • Describe recombinant DNA techniques and their applications in molecular biology procedures.
  • Explain the important features of the enzymes and cloning vectors commonly used, and choose an appropriate vector for a specific task.
  • Describe how DNA can be introduced into cells with the ultimate goal of gene therapy.
  • Explain how DNA sequencing is carried out, how the techniques have developed over the years, and give some applications.
  • Recognise the important role of bioinformatics in modern 'Omics technologies, and carry out a bioinformatics analysis with example data.
  • Describe the main principles behind, and carry out, sequence similarity searches and sequence alignments.
  • Explain how polymorphisms can be used to map genes involved in disease.
  • Describe the structures of mobile retrotransposons within eukaryotic genomes, mobilisation mechanisms, and implications for phenotype.
  • Define Epigenetics & Epigenomics, understanding the mechanisms involved and their function and describe the methods used to analyse the Epigenome.

Syllabus

The module covers several major topics in bioinformatics and DNA technology including an introduction to bioinformatics and its role in modern 'Omics technologies; developments in DNA sequencing technologies; bioinformatic analyses of DNA; sequence alignment and biological databases; recombinant DNA techniques-involving the use of different types of vector and host cells; molecular transactions involving DNA (e.g. recombination and transposition) and Epigenomics.

Special Features

N/A

Learning and Teaching

Teaching and learning methods

Lectures, independent study and involvement in a module assignment on bioinformatics.

TypeHours
Independent Study126
Lecture24
Total study time150

Assessment

Summative

MethodPercentage contribution
Assignment 25%
Written exam  (2 hours) 75%

Referral

MethodPercentage contribution
Assignment 25%
Written exam  (2 hours) 75%

Linked modules

Pre-requisites: BIOL1007 OR BIOL1010.

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