Project Overview
The control system is highly complex and, typical of such biological systems, there are multiple complementary physiological mechanisms working in parallel. There are indications that even in healthy individuals there are differences in the manner and the extent to which they control the flow. Understanding these may be key to achieving accurate detection of potentially dangerous impairment of regulatory function and thus to protecting the brains of vulnerable patients.
Our main research effort is directed at developing more robust methods of detecting the activities of the control system. This involves testing modified experimental procedures, and more sophisticated approaches in the analysis of data (traces of blood pressure, blood flow, heart-rate etc.). It is in the latter area where we have made most progress, so far.
This research work is being carried out with colleagues at the University Hospital Southampton NHS Foundation Trust, the Universities of Leicester and Oxford, as well as collaborators across the world through the Cerebral Autoregulation Research Network (CARNet http://www.car-net.org/).